Document Detail

Cosmetic permanent fillers for soft tissue augmentation: a new contraindication for interferon therapies.
MedLine Citation:
PMID:  17438184     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Most of the new fillers used for soft tissue augmentation in aesthetic dermatology are considered well tolerated, but very little data are available on their long-term tolerability, especially in patients receiving immunomodulatory therapy. OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection. The major affected sites had been treated 10 years before with Artecoll, a permanent filler containing polymethylmethacrylate. A treatment attempt with allopurinol was initiated while antiviral therapy was continued and was successfully completed after 6 months. Despite significant improvement, extended plastic surgery was necessary for facial reconstruction. CONCLUSIONS: The normal host response to a cosmetic filler is a weak granulomatous reaction. Interferon and other immunostimulatory medications can lead to an exacerbation of this preexisting low-grade chronic inflammation that is quite similar to interferon-triggered sarcoidosis. This potential long-term risk has medicolegal implications for informed consent and for the potential use of both permanent fillers and interferon.
Joerg Fischer; Gisela Metzler; Martin Schaller
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  143     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-05-24     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507-10     Citation Subset:  AIM; IM    
Department of Dermatology, Eberhard-Karls-University Tübingen, Tübingen, Germany.
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MeSH Terms
Adjuvants, Immunologic / adverse effects
Antiviral Agents / administration & dosage,  adverse effects*
Cosmetic Techniques*
Granuloma, Foreign-Body / chemically induced,  pathology
Hepatitis C, Chronic / drug therapy
Interferon Alfa-2a / administration & dosage,  adverse effects*
Middle Aged
Polyethylene Glycols / administration & dosage,  adverse effects*
Polymethyl Methacrylate
Ribavirin / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antiviral Agents; 0/Artecoll; 0/Polyethylene Glycols; 0/peginterferon alfa-2a; 36791-04-5/Ribavirin; 76543-88-9/Interferon Alfa-2a; 9007-34-5/Collagen; 9011-14-7/Polymethyl Methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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