Document Detail


Cosmetic permanent fillers for soft tissue augmentation: a new contraindication for interferon therapies.
MedLine Citation:
PMID:  17438184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Most of the new fillers used for soft tissue augmentation in aesthetic dermatology are considered well tolerated, but very little data are available on their long-term tolerability, especially in patients receiving immunomodulatory therapy. OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection. The major affected sites had been treated 10 years before with Artecoll, a permanent filler containing polymethylmethacrylate. A treatment attempt with allopurinol was initiated while antiviral therapy was continued and was successfully completed after 6 months. Despite significant improvement, extended plastic surgery was necessary for facial reconstruction. CONCLUSIONS: The normal host response to a cosmetic filler is a weak granulomatous reaction. Interferon and other immunostimulatory medications can lead to an exacerbation of this preexisting low-grade chronic inflammation that is quite similar to interferon-triggered sarcoidosis. This potential long-term risk has medicolegal implications for informed consent and for the potential use of both permanent fillers and interferon.
Authors:
Joerg Fischer; Gisela Metzler; Martin Schaller
Related Documents :
20825624 - Mixed treatment comparison meta-analysis evaluating the relative efficacy of nucleos(t)...
7906384 - A comparative trial of didanosine or zalcitabine after treatment with zidovudine in pat...
1663464 - Treatment of a patient with vulvar vestibulitis by intramuscular interferon beta; a cas...
18045284 - Therapeutic efficacy of sequential and simultaneous treatments with interferon-alpha an...
19005374 - Endovascular treatment of intracranial aneurysms using matrix coils: short- and mid-ter...
24105314 - The acute prescription of oxygen in orthopaedic trauma patients.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  143     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-05-24     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507-10     Citation Subset:  AIM; IM    
Affiliation:
Department of Dermatology, Eberhard-Karls-University Tübingen, Tübingen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / adverse effects
Antiviral Agents / administration & dosage,  adverse effects*
Collagen*
Cosmetic Techniques*
Face*
Female
Granuloma, Foreign-Body / chemically induced,  pathology
Hepatitis C, Chronic / drug therapy
Humans
Injections
Interferon Alfa-2a / administration & dosage,  adverse effects*
Middle Aged
Polyethylene Glycols / administration & dosage,  adverse effects*
Polymethyl Methacrylate
Ribavirin / administration & dosage,  adverse effects*
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antiviral Agents; 0/Artecoll; 0/Polyethylene Glycols; 0/peginterferon alfa-2a; 36791-04-5/Ribavirin; 76543-88-9/Interferon Alfa-2a; 9007-34-5/Collagen; 9011-14-7/Polymethyl Methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformation...
Next Document:  Oral lichen planus: a case series with emphasis on therapy.