| Cosmetic permanent fillers for soft tissue augmentation: a new contraindication for interferon therapies. | |
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MedLine Citation:
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PMID: 17438184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Most of the new fillers used for soft tissue augmentation in aesthetic dermatology are considered well tolerated, but very little data are available on their long-term tolerability, especially in patients receiving immunomodulatory therapy. OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection. The major affected sites had been treated 10 years before with Artecoll, a permanent filler containing polymethylmethacrylate. A treatment attempt with allopurinol was initiated while antiviral therapy was continued and was successfully completed after 6 months. Despite significant improvement, extended plastic surgery was necessary for facial reconstruction. CONCLUSIONS: The normal host response to a cosmetic filler is a weak granulomatous reaction. Interferon and other immunostimulatory medications can lead to an exacerbation of this preexisting low-grade chronic inflammation that is quite similar to interferon-triggered sarcoidosis. This potential long-term risk has medicolegal implications for informed consent and for the potential use of both permanent fillers and interferon. |
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Authors:
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Joerg Fischer; Gisela Metzler; Martin Schaller |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 143 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-17 Completed Date: 2007-05-24 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 507-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Eberhard-Karls-University Tübingen, Tübingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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adverse effects Antiviral Agents / administration & dosage, adverse effects* Collagen* Cosmetic Techniques* Face* Female Granuloma, Foreign-Body / chemically induced, pathology Hepatitis C, Chronic / drug therapy Humans Injections Interferon Alfa-2a / administration & dosage, adverse effects* Middle Aged Polyethylene Glycols / administration & dosage, adverse effects* Polymethyl Methacrylate Ribavirin / administration & dosage, adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Antiviral Agents; 0/Artecoll; 0/Polyethylene Glycols; 0/peginterferon alfa-2a; 36791-04-5/Ribavirin; 76543-88-9/Interferon Alfa-2a; 9007-34-5/Collagen; 9011-14-7/Polymethyl Methacrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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