Document Detail

Cosmeceutical properties of levan produced by Zymomonas mobilis.
MedLine Citation:
PMID:  16538295     Owner:  NLM     Status:  MEDLINE    
Levan, a polysaccharide that can be produced by both plants and microorganisms, is a sugar polymer composed of fructose, with beta-2,6 linkages. Here, we have attempted to assess the possible use of levan produced by Zymomonas mobilis as a cosmeceutical ingredient. In service of this goal, we assessed a host of levan's properties, including its moisturizing effects, cell cytotoxicity, cell proliferation effects, and anti-inflammation effects. Levan exhibited a moisturizing effect that was almost exactly the same as that evidenced by hyaluronic acid, as well as a similar cell proliferation effect in human fibroblast and keratinocyte cell lines. Moreover, in our cell proliferation test, which was conducted using bio-artificial skin constructed via 3-dimensional (3-D) culture after the induction of primary skin inflammation with 0.05% sodium lauryl sulfate (SLS), cell viability in the presence of levan (0.01 mg/ml, 0.05 mg/ml) was determined to be higher than cell viability in the absence of levan. In our anti-inflammation test, which was also conducted using 3-D artificial skin, and which involved the measurement of a quantity of secreted interleukin-1alpha (IL-1alpha), a pre-inflammatory mediator induced by SLS, we determined that the quantity of IL-1alpha in the 3-D artificial skin treated with 0.01 mg/ml and 0.05 mg/ml of levan was less than that registered in a skin sample that had been treated only with SLS. In this study, we determined that levan exerted an anti-inflammatory effect against inflammatory reactions to skin irritants, and also that levan exerted a cell-proliferative effect in bio-artificial skin, thereby indicating its potential applicability as a cosmeceutical agent.
Ki Ho Kim; Chan Bok Chung; Young Heui Kim; Ki Soo Kim; Chang Sung Han; Chul Ho Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cosmetic science     Volume:  56     ISSN:  1525-7886     ISO Abbreviation:  J Cosmet Sci     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2006-03-15     Completed Date:  2006-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814276     Medline TA:  J Cosmet Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-406     Citation Subset:  IM    
R&D Center, Bioland Ltd., Cheonan 330-863, Korea.
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MeSH Terms
Anti-Inflammatory Agents / chemistry,  metabolism,  pharmacology,  toxicity
Carbohydrate Sequence
Cell Proliferation / drug effects
Cosmetics / chemistry,  metabolism,  pharmacology*,  toxicity
Emollients / chemistry,  metabolism,  pharmacology,  toxicity
Fibroblasts / cytology,  drug effects
Fructans / chemistry,  metabolism,  pharmacology*,  toxicity
Keratinocytes / cytology,  drug effects
Microscopy, Electron, Transmission
Molecular Sequence Data
Molecular Weight
Nuclear Magnetic Resonance, Biomolecular
Polysaccharides, Bacterial / chemistry,  metabolism,  pharmacology*,  toxicity
Skin / drug effects*,  metabolism
Zymomonas / chemistry,  metabolism*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cosmetics; 0/Emollients; 0/Fructans; 0/Polysaccharides, Bacterial; 9013-95-0/levan

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