Document Detail


Cosinor analysis of diurnal changes of the reduced glutathione level in the blood, brain, liver and kidneys of mice, induced by ACTH administration.
MedLine Citation:
PMID:  2823515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of a single dose of ACTH(100 I.U. /kg body weight) on the diurnal rhythm of reduced glutathione (GSH) was studied in the blood and brain, liver and kidney homogenates of male mice. Cosinor analysis revealed that ACTH induces changes in the mean diurnal amount of GSH in the blood, brain, liver and kidneys. At the same time, GSH amplitudes in the blood and kidneys increased significantly, whereas in the case of brain and liver they decreased markedly. Moreover, it was found that ACTH induces a shift in GSH acrophases in the blood, brain, liver and kidneys as compared with the control values.
Authors:
H Lach; J Surowiak; K Dziubek; S Krawczyk; W Szaroma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta biologica Hungarica     Volume:  37     ISSN:  0236-5383     ISO Abbreviation:  Acta. Biol. Hung.     Publication Date:  1986  
Date Detail:
Created Date:  1987-12-08     Completed Date:  1987-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8404358     Medline TA:  Acta Biol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  IM    
Affiliation:
Department of Animal Physiology, Teacher Training College, Kraków, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / pharmacology*
Animals
Brain / metabolism
Circadian Rhythm / drug effects*
Glutathione / blood,  metabolism*
Kidney / metabolism
Liver / metabolism
Male
Mice
Tissue Distribution
Chemical
Reg. No./Substance:
70-18-8/Glutathione; 9002-60-2/Adrenocorticotropic Hormone

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