Document Detail


Cortisol and severe fatigue: a longitudinal study in adolescent girls.
MedLine Citation:
PMID:  17287088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatigue is a common complaint among adolescents, especially in girls, and is associated with high rates of school absenteeism. Severe fatigue is often accompanied by psychological and physical symptoms. In the chronic fatigue syndrome (CFS) functioning of the hypothalamic-pituitary-adrenal (HPA)-axis has previously been found to be altered. The aim of the present study was to investigate whether cortisol production is deviant in fatigued adolescent girls from the general population and to study longitudinal changes in fatigue in association with possible changes in HPA-axis functioning. In the cross-sectional part of the study the cortisol response to awakening (CAR) and to a low-dose oral dexamethasone were examined in a group of fatigued adolescent girls (n=87) in comparison to a non-fatigued control group (n=77). Questionnaires regarding fatigue, depression, anxiety, sleep quality, somatic symptoms and CFS-related symptoms were filled out. Follow up measurements were performed after 6 and 12 months. While the fatigued and non-fatigued group differed remarkably on all symptom self-reports, no differences between groups in CAR and response to dexamethasone were observed. Girls in the fatigued group remained fatigued over time and reported high levels of other psychological and physical symptoms during the whole year of the study. The CAR varied between time points but correlated non-systematically with situational characteristics or symptom reports. We conclude that trait-like fatigue, as measured in a sample of adolescent girls from a high school population, is not reflected in a dysregulation as assessed on the level of salivary cortisol after awakening.
Authors:
Maike Ter Wolbeek; Lorenz J P van Doornen; Luc E Coffeng; Annemieke Kavelaars; Cobi J Heijnen
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Publication Detail:
Type:  Journal Article     Date:  2007-02-06
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  32     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-82     Citation Subset:  IM    
Affiliation:
Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Office KC03.068.0, P.O. Box 85090, 3508 AB, Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anxiety / blood,  psychology
Area Under Curve
Depression / blood,  psychology
Fatigue / blood*,  psychology*
Female
Humans
Hydrocortisone / blood*
Hypothalamo-Hypophyseal System / physiology
Life Change Events
Longitudinal Studies
Questionnaires
Saliva / metabolism
Sleep / physiology
Wakefulness / physiology
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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