Document Detail


Cortisol metabolism in hypertensive patients who do and do not develop hypokalemia from diuretics.
MedLine Citation:
PMID:  7662229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deficiency of 11 beta-hydroxysteroid dehydrogenase causes hypertension and hypokalemia. To test whether hypertensive patients who develop hypokalemia when treated with diuretics have low levels of activity of this enzyme as a metabolic predisposition to the development of hypokalemia, we measured urinary cortisone, cortisol, tetrahydrocortisol, tetrahydrocortisone, and creatinine in 42 hypertensive patients who either did or did not become hypokalemic on hydrochlorothiazide. The mean ratios of cortisone to cortisol, tetrahydrocortisone to tetrahydrocortisol, tetrahydrocortisol to cortisol, and cortisol to creatinine did not differ between the two groups. We conclude that hypertensives who develop hypokalemia on diuretics do not have low activity of this enzyme. They also do not appear to have low ring A reduction or higher cortisol secretion rates compared with hypertensives who do not develop hypokalemia. We failed to find a metabolic predisposition to the development of hypokalemia by diuretic treatment.
Authors:
D L Santini; B J Lorenzo; T Koufis; M M Reidenberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  8     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-12     Completed Date:  1995-10-12     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  516-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Cornnell University Medical College, New York, New York 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
11-beta-Hydroxysteroid Dehydrogenases
Adult
Cortisone / urine
Creatinine / urine
Humans
Hydrochlorothiazide / adverse effects*
Hydrocortisone / urine*
Hydroxysteroid Dehydrogenases / deficiency*
Hypertension / drug therapy*,  metabolism
Hypokalemia / chemically induced*
Potassium / blood
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone; 53-06-5/Cortisone; 58-93-5/Hydrochlorothiazide; 60-27-5/Creatinine; 7440-09-7/Potassium; EC 1.1.-/Hydroxysteroid Dehydrogenases; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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