Document Detail

Cortisol levels and vigilance in eating disorder patients.
MedLine Citation:
PMID:  1484914     Owner:  NLM     Status:  MEDLINE    
Elevated plasma levels of cortisol, as well as deficits in cognitive processes such as attention, have been observed in patients with eating disorders. The association between plasma cortisol and performance in vigilance task was studied in 17 patients with bulimia nervosa or anorexia nervosa during the acute phase of their eating disorder. In comparison to normal young women, the patients had a significantly lower hit rate in a discrimination task and showed an impaired perceptual sensitivity index. They also displayed significantly longer reaction times to hits, but not to false alarms. Cortisol levels of the patients were significantly higher than those of the normal controls. When patients were divided according to their median cortisol level, the patients with higher levels performed significantly more poorly than did the patients with lower levels. In the total patient sample, cortisol levels showed a significant negative correlation with hit-rate (r = -.54) and a significant positive correlation with reaction time to hits (r = .70). Other clinical characteristics were not related to cognitive performance. These results suggest a possible role of cortisol in the development of attentional deficits in eating disorder patients.
R G Laessle; M Fischer; M M Fichter; K M Pirke; J C Krieg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  17     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-02-17     Completed Date:  1993-02-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  475-84     Citation Subset:  IM    
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany.
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MeSH Terms
Anorexia Nervosa / blood*,  psychology
Arousal / physiology*
Attention / physiology*
Bulimia / blood*,  psychology
Depression / blood,  psychology
Neuropsychological Tests
Personality Inventory
Psychomotor Performance / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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