Document Detail

Cortisol levels and very early pregnancy loss in humans.
MedLine Citation:
PMID:  16495411     Owner:  NLM     Status:  MEDLINE    
Maternal stress is commonly cited as an important risk factor for spontaneous abortion. For humans, however, there is little physiological evidence linking miscarriage to stress. This lack of evidence may be attributable to a paucity of research on maternal stress during the earliest gestational stages. Most human studies have focused on "clinical" pregnancy (>6 weeks after the last menstrual period). The majority of miscarriages, however, occur earlier, within the first 3 weeks after conception (approximately 5 weeks after the last menstrual period). Studies focused on clinical pregnancy thus miss the most critical period for pregnancy continuance. We examined the association between miscarriage and levels of maternal urinary cortisol during the first 3 weeks after conception. Pregnancies characterized by increased maternal cortisol during this period (within participant analyses) were more likely to result in spontaneous abortion (P < 0.05). This evidence links increased levels in this stress marker with a higher risk of early pregnancy loss in humans.
Pablo A Nepomnaschy; Kathleen B Welch; Daniel S McConnell; Bobbi S Low; Beverly I Strassmann; Barry G England
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-22
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  103     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-15     Completed Date:  2006-04-17     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3938-42     Citation Subset:  IM    
Department of Anthropology, 1085 South University Avenue, University of Michigan, Ann Arbor, MI 48109, USA.
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MeSH Terms
Abortion, Spontaneous / etiology,  urine*
Biological Markers / urine
Gestational Age
Hydrocortisone / urine*
Models, Biological
Pregnancy Outcome
Risk Factors
Stress, Physiological / complications,  urine
Reg. No./Substance:
0/Biological Markers; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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