Document Detail


Cortisol inhibition of vasopressin and ACTH responses to arterial hypotension in conscious dogs.
MedLine Citation:
PMID:  2154137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the role of cortisol as a feedback inhibitor of the vasopressin response to arterial hypotension. Conscious dogs (n = 5) were each studied on 10 different days. There were five different pretreatments: 1) isotonic saline (control), 2) 5.5 or 3) 11 nmol cortisol.kg-1.min-1 iv for 30 min, 4) 6.8 pmol ACTH-(1-24).kg-1.min-1 iv for 30 min, or 5) 1.5 mg dexamethasone im given the night before experimentation. These pretreatments were followed by a stimulus period (30 min) during which mean arterial pressure was decreased a moderate (-19 +/- 1 mmHg) or severe (-29 +/- 1 mmHg) degree with a controlled infusion of intravenous sodium nitroprusside. The vasopressin response to moderate hypotension was not consistently inhibited by any of the pretreatments. In contrast, the large vasopressin response to severe hypotension in the control experiments (from 3.1 +/- 0.3 to 270 +/- 113 pg/ml) was significantly attenuated by cortisol infusion in a dose-dependent manner. Adrenocorticotropin infusion was more effective than dexamethasone as an inhibitor of the vasopressin response to severe hypotension. The data suggest that physiological increases in cortisol inhibit the large increase in vasopressin in response to severe arterial hypotension.
Authors:
H Raff; M M Skelton; A W Cowley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-05     Completed Date:  1990-03-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R64-9     Citation Subset:  IM    
Affiliation:
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / antagonists & inhibitors*,  blood
Animals
Arginine Vasopressin / antagonists & inhibitors*,  blood
Dexamethasone / pharmacology
Dogs
Feedback
Female
Hydrocortisone / blood,  pharmacology*
Hypotension / blood*
Male
Nitroprusside / pharmacology
Osmolar Concentration
Grant Support
ID/Acronym/Agency:
HL-29587/HL/NHLBI NIH HHS; HL-39103/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 15078-28-1/Nitroprusside; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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