| Cortisol, dehydroepiandrosterone sulphate and dehydroepiandrosterone sulphate/cortisol ratio responses to physical stress in males are influenced by pubertal development. | |
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MedLine Citation:
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PMID: 17114910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the influence of chronological age and pubertal development on the hypothalamus-pituitary-adrenal (HPA) axis response to stress, we studied the possible correlations between male pubertal characteristics and salivary cortisol (C), DHEAS and the DHEAS/C ratio before (pre-stress) and after acute exercise-stress in young male volunteers (no. 87; 13.3+/-2.1 yr). In our overall study population, the mean pre-stress salivary C and DHEAS concentrations, significantly increased after exercise-related stress, whereas the DHEAS/C ratio significantly decreased. Pre-stress salivary C was positively correlated with chronological age, and after-stress salivary C concentration variations were negatively correlated with pubertal stage, mean testis volume and pre-stress salivary DHEAS. Furthermore, salivary DHEAS concentrations and the DHEAS/C ratio, before and after exercise stress, were positively correlated with chronological age, pubertal stage, pre-stress salivary testosterone (T), testis volume and body mass index (BMI). In contrast with late pubertal stages (P4, P5), young individuals at early stages of puberty (P1 to P3) showed higher C increase and lower DHEAS/C ratio after exercise-related stress. In conclusion, since C is also a mediator of stress-related negative effects on health and the DHEAS/C ratio has been hypothesized as an index for the degree to which an individual is buffered against the negative effects of stress, these data might suggest potentially increased stress-related risks at early stages of male puberty. |
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Authors:
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L Di Luigi; L Guidetti; C Baldari; M C Gallotta; P Sgrò; F Perroni; F Romanelli; A Lenzi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 29 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-11-20 Completed Date: 2007-02-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 796-804 Citation Subset: IM |
Affiliation:
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Unit of Endocrinology, Department of Health Sciences, University of Rome IUSM, Rome, Italy. iusm.endocrinol@iusm.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Dehydroepiandrosterone Sulfate / analysis* Exercise / physiology Human Development / physiology Humans Hydrocortisone / analysis* Male Puberty / physiology* Puberty, Delayed / pathology Puberty, Precocious / pathology Saliva / chemistry Stress, Physiological / pathology* |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 651-48-9/Dehydroepiandrosterone Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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