Document Detail

Cortisol circadian rhythm and 24-hour Holter arterial pressure in OSAS patients.
MedLine Citation:
PMID:  16433255     Owner:  NLM     Status:  MEDLINE    
Obstructive sleep apnea syndrome (OSAS) is a syndrome in which the principal symptom is apnea during sleep. Hypoxia in OSAS is a stress condition, which when prolonged in time, could alter hypothalamo-hypophysial-suprarenal control and the cortisol cicadian rhythm. We studied 28 patients with OSAS (30-60 years old), 20 female and 8 male. We calculated the OSAS class according to the Simmons classification. Twenty of the 28 patients maintained unmodified cortisol circadian rhythms, while 8 had cortisol levels more elevated in late and nocturnal hours. Holter monitoring showed arterial hypertension in 8 of the 28 patients (the same patients with cortisol circadian rhythm alteration). Our data seem to indicate that when the OSAS patients lack cortisol circadian rhythm they are having arterial hypertension.
C Parlapiano; M C Borgia; A Minni; N Alessandri; I Basal; M Saponara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine research     Volume:  31     ISSN:  0743-5800     ISO Abbreviation:  Endocr. Res.     Publication Date:  2005  
Date Detail:
Created Date:  2006-01-25     Completed Date:  2006-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8408548     Medline TA:  Endocr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
Dipartimento di Scienze Cliniche, Endocrinologia, Policlinico Umberto I, Università degli Studi di Roma La Sapienza, Rome, Italy.
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MeSH Terms
Blood Pressure / physiology*
Circadian Rhythm / physiology
Electrocardiography, Ambulatory
Hydrocortisone / blood*
Middle Aged
Sleep Apnea, Obstructive / blood*,  physiopathology*
Reg. No./Substance:

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