Document Detail


Cortisol circadian rhythm and 24-hour Holter arterial pressure in OSAS patients.
MedLine Citation:
PMID:  16433255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obstructive sleep apnea syndrome (OSAS) is a syndrome in which the principal symptom is apnea during sleep. Hypoxia in OSAS is a stress condition, which when prolonged in time, could alter hypothalamo-hypophysial-suprarenal control and the cortisol cicadian rhythm. We studied 28 patients with OSAS (30-60 years old), 20 female and 8 male. We calculated the OSAS class according to the Simmons classification. Twenty of the 28 patients maintained unmodified cortisol circadian rhythms, while 8 had cortisol levels more elevated in late and nocturnal hours. Holter monitoring showed arterial hypertension in 8 of the 28 patients (the same patients with cortisol circadian rhythm alteration). Our data seem to indicate that when the OSAS patients lack cortisol circadian rhythm they are having arterial hypertension.
Authors:
C Parlapiano; M C Borgia; A Minni; N Alessandri; I Basal; M Saponara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine research     Volume:  31     ISSN:  0743-5800     ISO Abbreviation:  Endocr. Res.     Publication Date:  2005  
Date Detail:
Created Date:  2006-01-25     Completed Date:  2006-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8408548     Medline TA:  Endocr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
Affiliation:
Dipartimento di Scienze Cliniche, Endocrinologia, Policlinico Umberto I, Università degli Studi di Roma La Sapienza, Rome, Italy. papitebe@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / physiology*
Circadian Rhythm / physiology
Electrocardiography, Ambulatory
Female
Humans
Hydrocortisone / blood*
Male
Middle Aged
Sleep Apnea, Obstructive / blood*,  physiopathology*
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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