| Cortisol catabolism by lymphocytes of patients with systemic lupus erythematosus and rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 2313669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have shown that low cortisol catabolism by lymphocytes correlates with a high sensitivity of the cells to the steroid. In the present study, we aimed to assess whether high resistance to corticosteroid treatment correlates with a high rate of cortisol catabolism by lymphocytes. Since patients with systemic lupus erythematosus (SLE) usually require high doses of corticosteroids, while patients with rheumatoid arthritis (RA) respond to relatively low doses of steroids, we compared the capability of lymphocytes of patients with SLE and RA to catabolize cortisol. The rate of cortisol catabolism obtained with the RA group was not significantly different from that obtained with the control group. The catabolism of cortisol by lymphocytes of the SLE group was significantly higher than both the control group (p less than 0.05) and the RA group (p less than 0.01). A significant correlation was demonstrated between the SLE disease activity index and rates of cortisol catabolism attained by lymphocytes of SLE patients (p less than 0.001). |
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Authors:
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A Klein; D Buskila; D Gladman; B Bruser; A Malkin |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of rheumatology Volume: 17 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-04-16 Completed Date: 1990-04-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 30-3 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry, Sunnybrook Medical Centre, Toronto, ON. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Adult Aged Arthritis, Rheumatoid / blood*, drug therapy Drug Resistance Female Humans Hydrocortisone / metabolism* Lupus Erythematosus, Systemic / blood*, drug therapy Lymphocytes / metabolism* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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