Document Detail


Cortisol secretory parameters in young exercisers in relation to LH secretion and bone parameters.
MedLine Citation:
PMID:  22671919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Amenorrhoea and low bone density are common in excessive exercisers, yet endocrine factors that differentiate adolescent amenorrhoeic exercisers (AE) from eumenorrhoeic exercisers (EE) are unclear. We have previously reported that high ghrelin and low leptin predict lower LH secretion in AE. Leptin and ghrelin impact cortisol secretion, and hypercortisolaemia can inhibit LH pulsatility. We hypothesized that higher cortisol secretion in young endurance weight-bearing AE compared with EE and nonexercisers predicts lower LH secretion, lower levels of a bone formation marker and higher levels of a bone resorption marker.
DESIGN: Cross-sectional.
SUBJECTS: We studied 21 AE, 18 EE and 20 nonexercisers aged 14-21 years (BMI 10th-90th%iles).
MEASUREMENTS: Subjects underwent frequent sampling (11 p.m. to 7 a.m.) to assess cortisol, ghrelin, leptin and LH secretory dynamics. Fasting levels of a bone formation (P1NP) and bone resorption (CTX) marker were measured.
RESULTS: BMI did not differ among groups. Cortisol pulse amplitude, mass, half-life and area under the curve (AUC) were highest in AE (P = 0.04, 0.007, 0.04 and 0.003) and were associated inversely with fat mass (r = -0.29, -0.28 and -0.35, P = 0.03, 0.04 and 0.007). We observed inverse associations between cortisol and LH AUC (r = -0.36, P = 0.008), which persisted after controlling for fat mass, leptin and ghrelin AUC. Cortisol correlated positively with CTX in EE and inversely with P1NP in nonexercisers.
CONCLUSIONS: Higher cortisol secretion in AE compared with EE and nonexercisers is associated with lower LH secretion. Effects of leptin and ghrelin on LH secretion may be mediated by increased cortisol.
Authors:
Kathryn E Ackerman; Kamal T Patel; Gabriela Guereca; Lisa Pierce; David B Herzog; Madhusmita Misra
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Clinical endocrinology     Volume:  78     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-23     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  114-9     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amenorrhea / metabolism
Bone Density
Bone and Bones / metabolism*
Cross-Sectional Studies
Exercise / physiology*
Female
Ghrelin / secretion
Humans
Hydrocortisone / secretion*
Leptin / secretion
Luteinizing Hormone / secretion*
Young Adult
Grant Support
ID/Acronym/Agency:
1 R01 HD060827-01A1/HD/NICHD NIH HHS; 1 UL1 RR025758-01/RR/NCRR NIH HHS; R01 HD060827/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Leptin; 9002-67-9/Luteinizing Hormone; WI4X0X7BPJ/Hydrocortisone
Comments/Corrections

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