Document Detail


Cortisol, 11-desoxycortisol, and 21-desoxycortisol concentrations in amniotic fluid during normal pregnancy.
MedLine Citation:
PMID:  6967697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concentrations of unconjugated cortisol, 11-desoxycortisol, and 21-desoxycortisol were measured by radioimmunoassay in amniotic fluid throughout gestation. Cortisol levels rose from a median of 6.5 nanograms per milliliter prior to 20 weeks to 13.9 ng/ml at 28 to 37 weeks. Median levels of 11-desoxycortisol and 21-desoxycortisol were 2.6 ng/ml and 0.21 ng/ml, respectively, and did not change with advancing gestation. These normal values provide a basis for the application of assays of 11-desoxycortisol and 21-desoxycortisol in amniotic fluid in the prenatal diagnosis of congenital adrenal hyperplasia.
Authors:
J Blankstein; K Fujieda; F I Reyes; C Faiman; J S Winter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  137     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1980-10-24     Completed Date:  1980-10-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  781-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
17-Hydroxycorticosteroids / analysis*
Amniotic Fluid / analysis*
Cortodoxone / analysis*
Female
Gestational Age
Humans
Hydrocortisone / analysis*
Pregnancy*
Steroid 11-beta-Hydroxylase / analysis
Steroid 21-Hydroxylase / analysis
Chemical
Reg. No./Substance:
0/17-Hydroxycorticosteroids; 152-58-9/Cortodoxone; 50-23-7/Hydrocortisone; 641-77-0/21-deoxycortisol; EC 1.14.15.4/Steroid 11-beta-Hydroxylase; EC 1.14.99.10/Steroid 21-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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