Document Detail

Corticotropin-releasing hormone, stress and human reproduction: an update.
MedLine Citation:
PMID:  20412987     Owner:  NLM     Status:  MEDLINE    
The stress system has suppressive effects on female and male reproductive function. Corticotrophin-releasing hormone (CRH), the principal regulator of stress, has been identified in the female and male reproductive system. Reproductive CRH participates in various reproductive functions that have an inflammatory component, where it serves as an autocrine and paracrine modulator. These include ovarian and endometrial CRH, which may participate in the regulation of steroidogenesis and the inflammatory processes of the ovary (ovulation and luteolysis) and the endometrium (decidualization and blastocyst implantation) and placental CRH, which is secreted mostly during the latter half of pregnancy and is responsible for the onset of labor. It has been suggested that there is a "CRH placental clock" which determines the length of gestation and the timing of parturition and delivery. The potential use of CRH-antagonists is presently under intense investigation. CRH-R1 antagonists have been used in animal studies to elucidate the role of CRH in blastocyst implantation and invasion, early fetal immunotolerance and premature labor. The present review article focuses on the potential roles of CRH on the physiology and pathophysiology of reproduction and highlights its participation in crucial steps of pregnancy, such as implantation, fetal immune tolerance, parturition and fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis.
S N Kalantaridou; E Zoumakis; A Makrigiannakis; L G Lavasidis; T Vrekoussis; G P Chrousos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  85     ISSN:  1872-7603     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  33-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Ioannina Medical School, Ioannina, Greece.
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MeSH Terms
Corticotropin-Releasing Hormone / physiology*
Hypothalamo-Hypophyseal System / physiology
Pituitary-Adrenal System / physiology
Pregnancy / physiology*
Reproduction / physiology*
Stress, Physiological / physiology*
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone

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