Document Detail


Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala.
MedLine Citation:
PMID:  1596084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin-releasing hormone in infant rats was investigated. Electrographic and behavioral phenomena were monitored in 42 rat pups aged 5 to 22 days. Rat pups carried bipolar electrodes implanted in subcortical limbic structures, as well as cortical electrodes and intracerebroventricular cannulae. The administration of corticotropin-releasing hormone produced age-specific seizures within minutes, which correlated with rhythmic amygdala discharges. Paroxysmal hippocampal and cortical discharges developed subsequently in some rats. Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala.
Authors:
T Z Baram; E Hirsch; O C Snead; L Schultz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  31     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-02     Completed Date:  1992-07-02     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  488-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Amygdala / physiology*
Animals
Animals, Newborn
Behavior, Animal / drug effects
Corticotropin-Releasing Hormone* / pharmacology
Dose-Response Relationship, Drug
Electroencephalography
Electromyography
Jaw / physiopathology
Myoclonus / physiopathology
Rats
Rats, Inbred Strains
Seizures / chemically induced*,  physiopathology
Stereotyped Behavior
Grant Support
ID/Acronym/Agency:
K08 NS001307/NS/NINDS NIH HHS; K08 NS001307-05/NS/NINDS NIH HHS; NS01307/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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