Document Detail

Corticotropin-releasing hormone in maternal and cord plasma in pre-eclampsia.
MedLine Citation:
PMID:  1851489     Owner:  NLM     Status:  MEDLINE    
The concentration of corticotropin-releasing hormone (CRH) in maternal plasma increases greatly during the last trimester of normal pregnancy. This CRH has been proposed to originate from the placenta. We studied plasma immunoreactive CRH in 46 uncomplicated pregnancies, in 10 pregnant women with chronic hypertension, in 17 women with pregnancy-induced hypertension (PIH) and in 24 women with pre-eclampsia, and correlated it to the levels of corticotropin (ACTH) and cortisol. CRH levels were greatly increased in women with pre-eclampsia, less significantly in women with PIH, while no change was found in pregnant women with chronic hypertension. ACTH levels also were increased in pregnancies with pre-eclampsia or PIH and there was a positive correlation between CRH and ACTH levels. CRH levels in cord venous plasma were significantly increased in pregnancies with pre-eclampsia but cortisol did not show any significant increase. These findings suggest that placental release of CRH into the maternal and fetal circulation is increased in pre-eclampsia.
T Laatikainen; T Virtanen; R Kaaja; K Salminen-Lappalainen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  39     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-06-19     Completed Date:  1991-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  IM    
Department I, of Obstetrics and Gynecology, University of Helsinki, Finland.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Corticotropin-Releasing Hormone / blood*
Fetal Blood / chemistry*
Hydrocortisone / blood
Hypertension / metabolism*
Placenta / metabolism
Pre-Eclampsia / blood*
Pregnancy Trimester, Third
Reg. No./Substance:
50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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