| Corticotropin-releasing factor stimulants adenylate cyclase activity in the anterior pituitary gland. | |
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MedLine Citation:
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PMID: 6292603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ovine corticotropin-releasing factor (CRF) stimulates adenylate cyclase activity in rat anterior pituitary homogenate at an ED50 value of 70 nM. GTP increases the stimulatory effect of CRF on ]32p] cyclic AMP formation in a rat adenohypophysial particulate fraction and in bovine anterior pituitary plasma membranes. The present data show that CRF stimulates adenylate cyclase activity in the anterior pituitary gland at least partly through a guanyl nucleotide-dependent mechanism. |
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Authors:
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F Labrie; B Gagné; G Lefèvre |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Life sciences Volume: 31 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1982 Sep |
Date Detail:
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Created Date: 1983-01-19 Completed Date: 1983-01-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1117-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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biosynthesis*,
metabolism Animals Cattle Corticotropin-Releasing Hormone / pharmacology* Cyclic AMP Dose-Response Relationship, Drug Enzyme Induction Female Pituitary Gland, Anterior / enzymology* Rats Sheep / physiology |
| Chemical | |
Reg. No./Substance:
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60-92-4/Cyclic AMP; 9015-71-8/Corticotropin-Releasing Hormone; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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