| Corticotropin-releasing factor modulation of the ultrasonic vocalization rate of isolated rat pups. | |
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MedLine Citation:
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PMID: 7586494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of corticotropin-releasing factor (CRF) on ultrasonic vocalizations (USVs) and other behaviors of isolated rat pups was examined at 5/6-, 9/10-, and 13/14-days. The hypothesis tested was that central CRF affects USV rate biphasically: as endogenous CRF increases from low basal levels it initiates USV production, but at higher levels CRF diminishes USV production. As predicted, the largest doses of CRF (0.1 and 1 microgram) and of its antagonist alpha-helical CRF9-41 (aH-CRF; 20 micrograms) administered intracerebroventricularly (ICV) reduced USV rate compared to saline treatment during a 2-min isolation at ambient temperature in pups of all ages. Other behaviors were either unaffected or increased by drug treatment. Effects were not attributable to sedation or to a change in core temperature. Peripheral administration of 1 microgram CRF or 20 micrograms aH-CRF had no effect. When isolation occurred in a heated chamber containing soiled bedding from the home cage to minimize baseline USV rate, ICV-CRF (0.001, 0.01, 0.1, or 1 microgram) did not enhance the rate. The quieting ability of aH-CRF is evidence that central endogenous CRF enhances the rate of ongoing USVs during brief isolation; the quieting ability of CRF suggests that this peptide may also be responsible for the reduction in USV rate that normally occurs during more protracted isolation. However, CRF alone is not sufficient to induce vocalizing in quiet pups. |
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Authors:
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A T Harvey; M B Hennessy |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Brain research. Developmental brain research Volume: 87 ISSN: 0165-3806 ISO Abbreviation: Brain Res. Dev. Brain Res. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-11-30 Completed Date: 1995-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908639 Medline TA: Brain Res Dev Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 125-34 Citation Subset: IM |
Affiliation:
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Department of Psychology, Wright State University, Dayton, OH 45435, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects Body Temperature / drug effects Corticotropin-Releasing Hormone / pharmacology* Environment Female Male Rats Rats, Sprague-Dawley Reflex / drug effects Social Isolation* Sound Spectrography Vocalization, Animal / drug effects* |
| Chemical | |
Reg. No./Substance:
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9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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