Document Detail


Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y.
MedLine Citation:
PMID:  8518948     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Central administration of neuropeptide Y (NPY) exerts a potent orexigenic effect in rats, whereas injection of corticotropin-releasing factor (CRF) suppresses food intake. Anatomical evidence of NPY-containing terminals located in close proximity to CRF-containing neurons and terminals of the hypothalamus and amygdala suggests possible interactions of these neuropeptide systems in food-intake regulation. The present study examined the effect of local administration of the CRF antagonist, alpha-helical CRF9-41, or peripheral treatment with dexamethasone on NPY-induced hyperphagia. Injection of a 250-ng dose of alpha-hel CRF within the paraventricular nucleus (PVN) of the hypothalamus significantly potentiated the feeding induced by a 500-ng dose of NPY injected into the same locus. In contrast, feeding induced by administration of the 500-ng dose of NPY into the ventromedial hypothalamus (VMH) was not modified by intra-VMH pre-treatment with a 250-ng dose of CRF antagonist. No effects of NPY or alpha-hel CRF on feeding were observed after administration into the central nucleus of the amygdala. Systemic pre-treatment with the synthetic glucocorticoid dexamethasone at a dose known to downregulate the function of CRF neurons in the PVN (100 micrograms/kg) enhanced feeding induced by intra-PVN administration of a 500-ng dose of NPY. These results suggest that hypothalamic CRF systems in the PVN exert inhibitory control over NPY-induced food intake.
Authors:
S C Heinrichs; F Menzaghi; E M Pich; R L Hauger; G F Koob
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  611     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-29     Completed Date:  1993-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  18-24     Citation Subset:  IM    
Affiliation:
Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation / drug effects,  physiology*
Corticotropin-Releasing Hormone / pharmacology,  physiology*
Dexamethasone / pharmacology
Hypothalamo-Hypophyseal System / physiology
Male
Neurons / physiology*
Neuropeptide Y / antagonists & inhibitors*,  pharmacology
Paraventricular Hypothalamic Nucleus / drug effects,  physiology*
Pituitary-Adrenal System / physiology
Rats
Rats, Wistar
Grant Support
ID/Acronym/Agency:
06420//PHS HHS; 07456//PHS HHS; 26741//PHS HHS
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 50-02-2/Dexamethasone; 9015-71-8/Corticotropin-Releasing Hormone

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