| Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. | |
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MedLine Citation:
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PMID: 8518948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central administration of neuropeptide Y (NPY) exerts a potent orexigenic effect in rats, whereas injection of corticotropin-releasing factor (CRF) suppresses food intake. Anatomical evidence of NPY-containing terminals located in close proximity to CRF-containing neurons and terminals of the hypothalamus and amygdala suggests possible interactions of these neuropeptide systems in food-intake regulation. The present study examined the effect of local administration of the CRF antagonist, alpha-helical CRF9-41, or peripheral treatment with dexamethasone on NPY-induced hyperphagia. Injection of a 250-ng dose of alpha-hel CRF within the paraventricular nucleus (PVN) of the hypothalamus significantly potentiated the feeding induced by a 500-ng dose of NPY injected into the same locus. In contrast, feeding induced by administration of the 500-ng dose of NPY into the ventromedial hypothalamus (VMH) was not modified by intra-VMH pre-treatment with a 250-ng dose of CRF antagonist. No effects of NPY or alpha-hel CRF on feeding were observed after administration into the central nucleus of the amygdala. Systemic pre-treatment with the synthetic glucocorticoid dexamethasone at a dose known to downregulate the function of CRF neurons in the PVN (100 micrograms/kg) enhanced feeding induced by intra-PVN administration of a 500-ng dose of NPY. These results suggest that hypothalamic CRF systems in the PVN exert inhibitory control over NPY-induced food intake. |
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Authors:
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S C Heinrichs; F Menzaghi; E M Pich; R L Hauger; G F Koob |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 611 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-07-29 Completed Date: 1993-07-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 18-24 Citation Subset: IM |
Affiliation:
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Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation / drug effects, physiology* Corticotropin-Releasing Hormone / pharmacology, physiology* Dexamethasone / pharmacology Hypothalamo-Hypophyseal System / physiology Male Neurons / physiology* Neuropeptide Y / antagonists & inhibitors*, pharmacology Paraventricular Hypothalamic Nucleus / drug effects, physiology* Pituitary-Adrenal System / physiology Rats Rats, Wistar |
| Grant Support | |
ID/Acronym/Agency:
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06420//PHS HHS; 07456//PHS HHS; 26741//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 50-02-2/Dexamethasone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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