Document Detail


Corticotropin-releasing factor: effects on the autonomic nervous system and visceral systems.
MedLine Citation:
PMID:  2981744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corticotropin-releasing factor (CRF) acts within the central nervous system to modify the activity of the sympathetic and parasympathetic nervous systems, cardiovascular function, endocrine-pancreatic function, and carbohydrate metabolism. These changes in animal physiology induced by CRF provide a tenable basis for hypothesizing that this peptide may be physiologically involved in integrating the neuroendocrine, autonomic, cardiovascular, and metabolic responses to stressful stimuli. This hypothesis is supported by studies demonstrating that glucocorticoids or CRF receptor antagonists alter both the neuroendocrine and autonomic responses to stress.
Authors:
M R Brown; L A Fisher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Federation proceedings     Volume:  44     ISSN:  0014-9446     ISO Abbreviation:  Fed. Proc.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-02-28     Completed Date:  1985-02-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372771     Medline TA:  Fed Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / drug effects
Adrenocorticotropic Hormone / blood
Angiotensin II / pharmacology
Animals
Autonomic Nervous System / drug effects*,  physiology
Blood Pressure / drug effects
Cardiovascular System / drug effects
Corticosterone / pharmacology
Corticotropin-Releasing Hormone / pharmacology*,  physiology
Dogs
Epinephrine / blood
Heart Rate / drug effects
Hyperglycemia / chemically induced
Norepinephrine / blood
Rats
Sympathetic Nervous System / drug effects
Grant Support
ID/Acronym/Agency:
AM26741/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 50-22-6/Corticosterone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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