Document Detail

Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats.
MedLine Citation:
PMID:  12559107     Owner:  NLM     Status:  MEDLINE    
Several kinds of stress such as psychological stress, restraint, and foot shock inhibit feeding behavior through corticotropin-releasing factor (CRF). In contrast, a mild tail pinch increases food intake in rats. Although dopamine and opioid are thought to be involved in tail-pinch-induced food intake, it is unknown whether CRF participates in this phenomenon. Therefore, we attempted to clarify this issue using rats. A 30-s tail pinch increased food intake in 30 min after the tail pinch, and this increase was blocked by intraperitoneal injection of CRF receptor type 1 selective antagonist. CRF increased food intake in 30 min after intracerebroventricular injection at a dose of 2 or 10 ng, and this increase was also blocked by CRF receptor type 1 antagonist. Tail-pinch- or CRF-induced food intake was blocked by naloxone, pimozide, and spiperone. These results suggest that CRF, through CRF receptor type 1 as well as opioid and dopaminergic systems, are involved in the mechanism of tail-pinch-induced food intake. The results also suggest that brain CRF has dual effects on food intake, hyperphagia and anorexia, in a stress-dependent manner.
S Samarghandian; H Ohata; N Yamauchi; T Shibasaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience     Volume:  116     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2003  
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-04-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  519-24     Citation Subset:  IM    
Copyright Information:
Copyright 2003 IBRO
Department of Physiology, Nippon Medical School, 1-1-5 Sendagi Bunkyo-ku, Tokyo 113-8602, Japan.
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MeSH Terms
Corticotropin-Releasing Hormone / pharmacology*
Dopamine / physiology*
Dopamine Antagonists / pharmacology
Eating / drug effects,  physiology*
Injections, Intraventricular
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Physical Stimulation
Pimozide / pharmacology
Pyridines / pharmacology
Pyrimidines / pharmacology
Rats, Wistar
Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors,  physiology
Receptors, Opioid / antagonists & inhibitors,  physiology*
Spiperone / pharmacology
Stress, Physiological / physiopathology*
Reg. No./Substance:
0/CRA1000; 0/CRF receptor type 1; 0/Dopamine Antagonists; 0/Narcotic Antagonists; 0/Pyridines; 0/Pyrimidines; 0/Receptors, Corticotropin-Releasing Hormone; 0/Receptors, Opioid; 2062-78-4/Pimozide; 465-65-6/Naloxone; 749-02-0/Spiperone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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