Document Detail


Corticotropin-releasing factor (CRF)-induced behaviors are modulated by intravenous administration of teneurin C-terminal associated peptide-1 (TCAP-1).
MedLine Citation:
PMID:  17644218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The teneurin C-terminal associated peptides (TCAP) are a recently discovered family of bioactive peptides that can attenuate aspects of the behavioral stress responses of rats. Because TCAP has some structural similarity to the corticotropin-releasing factor (CRF) family of peptides, and modulates elements of the stress response, TCAP may act to modulate CRF actions in vivo. This hypothesis was tested by investigating anxiety-related behaviors in male rats following repeated intravenous (IV) TCAP-1 administration with either an acute intracerebroventricular (ICV) or IV CRF challenge. TCAP-1 alone did not affect behavioral responses significantly, however did significantly affect CRF-regulated behaviors depending on CRF's mode of injection. In both the elevated plus-maze and the open field tests, TCAP-1 had an anxiolytic effect on ICV CRF responses as indicated by decreased stretched-attend postures in the elevated plus maze (p<0.05), and increased center time and center entries in the open field (p<0.05). However, prior TCAP-1 treatment has an anxiogenic effect on the IV CRF-induced behaviors (decreased center entries and total distance in the open field (p<0.05)). TCAP-1's actions are not mediated through acute changes in glucocorticoid levels and may occur via a central action in the brain. A fluorescently (FITC)-labeled TCAP-1 analog was IV-administered to investigate whether IV TCAP-1 has the potential to regulate central mechanisms by crossing the blood-brain barrier. FITC-TCAP-1 was detected in blood vessels and fibers in the brain indicating that uptake into the brain is a possible route for its interaction with CRF and its receptors. Thus, TCAP may modulate CRF-associated behaviors by a direct action in the CNS.
Authors:
Arij Al Chawaf; Karen Xu; Laura Tan; Franco J Vaccarino; David A Lovejoy; Susan Rotzinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-22
Journal Detail:
Title:  Peptides     Volume:  28     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1406-15     Citation Subset:  IM    
Affiliation:
Department of Cell and Systems Biology, University of Toronto, Toronto, Canada. arij.alchawaf@utoronto.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal* / drug effects
Brain / metabolism
Corticotropin-Releasing Hormone / pharmacology*
Fluorescein-5-isothiocyanate / metabolism
Injections, Intraventricular
Male
Maze Learning
Nerve Tissue Proteins / administration & dosage,  pharmacology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/TCAP-1 protein, mouse; 3326-32-7/Fluorescein-5-isothiocyanate; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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