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Corticotropin-releasing Hormone in Human Pregnancy and Parturition.
MedLine Citation:
PMID:  10370225     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The role of corticotropin-releasing hormone (CRH) in the regulation of pituitary adrenocorticotropin secretion and the stress response is well established. However, in recent years this peptide has been found to serve a number of functions outside the classic neuroendocrine domain. During pregnancy, CRH derived from the placenta is thought to play a crucial role in the regulation of foetal maturation and the timing of delivery, and CRH has also been implicated in the control of foetal-placental bloodflow. Abnormalities of the placental CRH system might be involved in the pathogenesis of preterm labour, foetal growth retardation and pre-eclampsia, which are the three leading causes of perinatal morbidity and mortality in developed countries.
Authors:
McLean; Smith
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  10     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-06-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  174-178     Citation Subset:  -    
Affiliation:
Department of Endocrinology, Westmead Hospital, Westmead, Sydney, NSW 2145, Australia.
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