| Corticotropin-releasing Hormone in Human Pregnancy and Parturition. | |
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MedLine Citation:
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PMID: 10370225 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The role of corticotropin-releasing hormone (CRH) in the regulation of pituitary adrenocorticotropin secretion and the stress response is well established. However, in recent years this peptide has been found to serve a number of functions outside the classic neuroendocrine domain. During pregnancy, CRH derived from the placenta is thought to play a crucial role in the regulation of foetal maturation and the timing of delivery, and CRH has also been implicated in the control of foetal-placental bloodflow. Abnormalities of the placental CRH system might be involved in the pathogenesis of preterm labour, foetal growth retardation and pre-eclampsia, which are the three leading causes of perinatal morbidity and mortality in developed countries. |
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Authors:
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McLean; Smith |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 10 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-06-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: 174-178 Citation Subset: - |
Affiliation:
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Department of Endocrinology, Westmead Hospital, Westmead, Sydney, NSW 2145, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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