Document Detail

Corticotropin and cortisol secretion after central 5-hydroxytryptamine-1A (5-HT1A) receptor activation: effects of 5-HT receptor and beta-adrenoceptor antagonists.
MedLine Citation:
PMID:  1968468     Owner:  NLM     Status:  MEDLINE    
To explore the involvement of 5-hydroxytryptamine-1A (5-HT1A) receptors in hypothalamic-pituitary-adrenal (HPA) axis regulation, various doses of ipsapirone (IPS), a centrally acting pyrimidinylpiperazine with considerable affinity and selectivity for 5-HT1A recognition sites, were administered to normal subjects. IPS dose-dependently increased plasma ACTH concentrations from -78 +/- 63 to 614 +/- 250 pmol.min/L (P less than 0.01) and plasma cortisol concentrations from -10.8 +/- 2.9 x 10(3) to 21.3 +/- 8.2 x 10(3) nmol.min/L (P less than 0.01) at a dose of 0.3 mg/kg in six men. The nonselective 5-HT receptor antagonist metergoline which acts at both 5-HT1 and 5-HT2 receptors partially blocked the HPA response to IPS in six women and three men. The mean maximal integrated ACTH response decreased from 746 +/- 297 to 40 +/- 146 pmol/min.L (P less than 0.05), and the increase in cortisol was attenuated from 22.9 +/- 9.9 x 10(3) to 11.9 +/- 6.3 x 10(3) nmol.min/L (P less than 0.05). The nonselective beta-adrenergic and selective 5-HT1A/1B receptor antagonist (+/-)pindolol was without effect on basal HPA activity, but completely antagonized the IPS-induced plasma ACTH and cortisol responses. The mean maximal integrated ACTH response decreased to 8.0 +/- 78 pmol.min/L (P less than 0.05), and the cortisol response was reduced to -2.3 +/- 6.5 x 10(3) nmol.min/L (P less than 0.05). The selective beta 1-adrenoceptor antagonist betaxolol did not significantly alter the IPS-induced HPA response.(ABSTRACT TRUNCATED AT 250 WORDS)
K P Lesch; K Söhnle; B Poten; G Schoellnhammer; R Rupprecht; H M Schulte
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  70     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-04     Completed Date:  1990-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  670-4     Citation Subset:  AIM; IM    
Department of Psychiatry, University of Würzburg, West Germany.
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MeSH Terms
Adrenergic beta-Agonists / pharmacology*
Adrenocorticotropic Hormone / blood*
Betaxolol / pharmacology
Biotransformation / drug effects
Hydrocortisone / blood*
Hypothalamo-Hypophyseal System / drug effects,  physiology
Metergoline / pharmacology
Pindolol / pharmacology
Pituitary-Adrenal System / drug effects,  physiology
Pyrimidines / pharmacology
Receptors, Serotonin / drug effects*,  physiology
Serotonin / pharmacology*
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Pyrimidines; 0/Receptors, Serotonin; 13523-86-9/Pindolol; 17692-51-2/Metergoline; 50-23-7/Hydrocortisone; 50-67-9/Serotonin; 63659-18-7/Betaxolol; 9002-60-2/Adrenocorticotropic Hormone; 92589-98-5/ipsapirone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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