| Corticotrophin-releasing Factor and Urocortin Inhibit System A Activity in Term Human Placental Villous Explants. | |
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MedLine Citation:
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PMID: 21093910 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CRF and urocortin inhibit placental system A activity. Chronic (48h) exposure of term placental villous explants to these hormones (10(-7)M) significantly reduced system A activity (Na(+)-dependent (14)C-methylaminoisobutyric acid uptake), whereas 1h exposure had no effect. We propose elevated CRF and urocortin contribute to FGR through negative regulation of placental system A activity. |
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Authors:
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A Giovannelli; S L Greenwood; M Desforges; C P Sibley; F Petraglia |
Publication Detail:
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Type: Journal Article Date: 2010-11-19 |
Journal Detail:
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Title: Placenta Volume: 32 ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: 99-101 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Obstetric and Gynecology, University of Siena, Siena, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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