Document Detail


Corticotrophin-releasing Factor and Urocortin Inhibit System A Activity in Term Human Placental Villous Explants.
MedLine Citation:
PMID:  21093910     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CRF and urocortin inhibit placental system A activity. Chronic (48h) exposure of term placental villous explants to these hormones (10(-7)M) significantly reduced system A activity (Na(+)-dependent (14)C-methylaminoisobutyric acid uptake), whereas 1h exposure had no effect. We propose elevated CRF and urocortin contribute to FGR through negative regulation of placental system A activity.
Authors:
A Giovannelli; S L Greenwood; M Desforges; C P Sibley; F Petraglia
Publication Detail:
Type:  Journal Article     Date:  2010-11-19
Journal Detail:
Title:  Placenta     Volume:  32     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Obstetric and Gynecology, University of Siena, Siena, Italy.
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