Document Detail

Corticotroph pituitary carcinoma: case report and literature review.
MedLine Citation:
PMID:  11740054     Owner:  NLM     Status:  MEDLINE    
Pituitary carcinomas, currently defined as primary adenohypophyseal neoplasms with evidence of either brain invasion or metastatic spread, are exceptionally rare. A case of corticotroph pituitary carcinoma is reported. A 17-year-old female first presented with an invasive and clinically non-functioning pituitary macroadenoma. The primary pituitary lesion lacked atypical histological features and retrospective immunohistochemical studies confirmed its corticotrophic nature. Repeated episodes of local recurrence followed together with the acquisition of severe Cushing's disease. Local disease control was not obtained despite repeated surgical decompression and courses of radiation therapy. Systemic dissemination with multiple bone metastases became manifest eleven years after the first presentation. Atypical histological features and Crooke's hyaline change were evident in both the recurrent and metastatic disease. She remains alive at last follow-up with severe complications relating to persisting sellar and metastatic disease and ongoing endocrine dysfunction. A further 32 cases of pituitary corticotroph carcinoma reported in English are reviewed to highlight the clinicopathological features of this rare form of pituitary neoplasm. Difficulties associated with the diagnosis and management of pituitary carcinoma are also discussed.
D J Holthouse; P D Robbins; R Kahler; N Knuckey; P Pullan
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Endocrine pathology     Volume:  12     ISSN:  1046-3976     ISO Abbreviation:  Endocr. Pathol.     Publication Date:  2001  
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9009288     Medline TA:  Endocr Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-41     Citation Subset:  IM    
Department of Neurosurgery, Sir Charles Gairdner Hospital, Perth, Western Australia.
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MeSH Terms
Adenoma / metabolism,  pathology*
Adrenocorticotropic Hormone / secretion*
Cushing Syndrome / pathology
Keratins / metabolism
Magnetic Resonance Imaging
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Pituitary Gland, Anterior / metabolism,  pathology*
Pituitary Neoplasms / metabolism,  pathology*
Reg. No./Substance:
68238-35-7/Keratins; 9002-60-2/Adrenocorticotropic Hormone

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