Document Detail


Corticotroph axis sensitivity after exercise: comparison between elite athletes and sedentary subjects.
MedLine Citation:
PMID:  17505155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Strenuous exercise activates the hypothalamic-pituitary-adrenal (HPA) axis. Several reports showed that physical training is associated with a decreased efficiency of the feedback control of HPA axis. The aims of the present study were: 1) to evaluate the differences in the mechanical, hormonal, and lactate responses to a high-intensity isokinetic exercise among different groups of competitive athletes (CA, no.=20) of power and endurance disciplines and sedentary controls (SED, no.=10); 2) to determine the effects of the training status on the HPA axis responsiveness following exercise, as indirectly evaluated by the rates of ACTH, cortisol, and DHEA recovery after exercise. CA and SED fulfilled eight sets of twenty concentric contractions of the knee extensors at 180 degrees/sec angular velocity throughout a constant range of motion (100 degrees). There was a rest period of 30 sec between each set and a 3-min rest period between the two legs. Before, immediately after the isokinetic exercise and at different times in the subsequent 120 min of recovery, blood and saliva were sampled to determine plasma ACTH, salivary cortisol, serum DHEA, and serum lactate concentrations. CA showed a higher cortisol response to exercise than SED, whereas no differences were found in the responses of ACTH, DHEA and lactate. In the athlete group the exercise-induced increases of ACTH, cortisol, and lactate were higher in power athletes with respect to endurance athletes. No differences were observed between athletes and SED in the rates of hormonal recovery after exercise: this finding does not support the concept that a reduced feedback control of HPA axis can represent a feature of trained individuals.
Authors:
M A Minetto; F Lanfranco; M Baldi; A Termine; H Kuipers; E Ghigo; A Rainoldi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  30     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-05-16     Completed Date:  2007-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  215-23     Citation Subset:  IM    
Affiliation:
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy. marcominetto@libero.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenocorticotropic Hormone / blood
Adult
Corticotrophs / metabolism*
Exercise / physiology*
Exercise Test / methods,  trends
Health Status
Humans
Hydrocortisone / blood
Hypothalamo-Hypophyseal System / metabolism*
Lactic Acid / blood
Male
Physical Fitness / physiology*
Pituitary-Adrenal System / metabolism*
Sports / physiology*
Chemical
Reg. No./Substance:
50-21-5/Lactic Acid; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

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