Document Detail

Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward.
MedLine Citation:
PMID:  16289609     Owner:  NLM     Status:  MEDLINE    
Work over the past decade has supported the idea that discrete aspects of appetitive motivation are differentially mediated by separate but interacting neurochemical systems within the nucleus accumbens (Acb). We review herein a series of studies in rats comparing the effects of manipulating Acb amino acid, opioid, acetylcholine, and dopamine systems on tests of free-feeding and food-reinforced operant responding. Results from our laboratory and in the literature support three general conclusions: (1) GABA output neurons localized exclusively within the Acb shell directly influence hypothalamic effector mechanisms for feeding motor patterns, but do not participate in the execution of more complex food-seeking strategies; (2) enkephalinergic neurons distributed throughout the Acb and caudate-putamen mediate the hedonic impact of palatable (high sugar/fat) foods, and these neurons are under modulatory control by striatal cholinergic interneurons; and (3) dopamine transmission in the Acb governs general motoric and arousal processes related to response selection and invigoration, as well as motor learning-related plasticity. These dissociations may reflect the manner in which these neurochemical systems differentially access pallido-thalamo-cortical loops reaching the voluntary motor system (in the case of opioids and dopamine), versus more restricted efferent connections to hypothalamic motor/autonomic control columns (in the case of Acb shell GABA and glutamate systems). Moreover, we hypothesize that while these systems work in tandem to coordinate the anticipatory and consummatory phases of feeding with hypothalamic energy-sensing substrates, the striatal opioid network evolved a specialized capacity to promote overeating of energy-dense foods beyond acute homeostatic needs, to ensure an energy reserve for potential future famine.
Ann E Kelley; Brian A Baldo; Wayne E Pratt; Matthew J Will
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2005-11-14
Journal Detail:
Title:  Physiology & behavior     Volume:  86     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-01     Completed Date:  2006-01-17     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-95     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / physiology
Amino Acids / pharmacology
Cerebral Cortex / physiology*
Dopamine / physiology
Eating / drug effects,  physiology,  psychology
Endorphins / physiology
Energy Metabolism / physiology*
Hypothalamus / physiology*
Neostriatum / physiology*
Nucleus Accumbens / physiology
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Endorphins; N9YNS0M02X/Acetylcholine; VTD58H1Z2X/Dopamine

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