| Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder. | |
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MedLine Citation:
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PMID: 21067900 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The basal ganglia represents a key component of the pathophysiological model for obsessive-compulsive disorder (OCD). This brain region is part of several neural circuits, including the orbitofronto-striatal circuit and dorsolateral prefronto-striatal circuit. There are, however, no published studies investigating those circuits at a network level in non-medicated patients with OCD. Resting state functional magnetic resonance imaging scans were obtained from 20 non-medicated patients with OCD and 23 matched healthy volunteers. Voxelwise statistical parametric maps testing strength of functional connectivity of three striatal seed regions of interest (ROIs) with remaining brain regions were calculated and compared between groups. We performed additional correlation analyses between strength of connectivity and the severity scores for obsessive-compulsive symptoms, depression, and anxiety in the OCD group. Positive functional connectivity with the ventral striatum was significantly increased (P(corrected)<.05) in the orbitofrontal cortex, ventral medial prefrontal cortex and dorsal lateral prefrontal cortex of subjects with OCD. There was no significant correlation between measures of symptom severity and the strength of connectivity (P(uncorrected)<.001). This is the first study to investigate the corticostriatal connectivity in non-medicated patients with OCD. These findings provide the first direct evidence supporting a pathophysiological model involving basal ganglia circuitry in OCD. |
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Authors:
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Y Sakai; J Narumoto; S Nishida; T Nakamae; K Yamada; T Nishimura; K Fukui |
Publication Detail:
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Type: Journal Article Date: 2010-11-09 |
Journal Detail:
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Title: European psychiatry : the journal of the Association of European Psychiatrists Volume: 26 ISSN: 1778-3585 ISO Abbreviation: Eur. Psychiatry Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111820 Medline TA: Eur Psychiatry Country: France |
Other Details:
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Languages: eng Pagination: 463-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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