Document Detail


Corticosterone response in a resident-intruder-paradigm depends on social state and coping style in adolescent male Balb-C mice.
MedLine Citation:
PMID:  17984949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Social stressors modulate the hypothalamic-pituitary-adrenal axis in rodents. However, reports on the association between corticosterone level and behavioural responses to the stressor are ambivalent. This may depend on the experimental paradigm, species- and strain-differences, duration of exposure to the stressor, but also on using either the social state (dominant or subordinate) or the coping style (proactive or passive) of an animal to correlate the corticosterone level with. DESIGN AND SETTING: We used male Balb-C mice in a resident-intruder paradigm. Adolescent intruders (aged five to eight weeks) were transferred into the cage of an adult resident (aged about four month) for five minutes. The interactions were video-taped for behavioural analysis. Ten minutes after the encounters, intruders were sacrificed and blood samples were collected. RESULTS: Dominant intruders showed offensive behaviours (attack, chase, tail tracking) and won most of the fights, whereas subordinate intrudes showed mainly submissive behaviours (flight, freezing) and were further classified into active and passive subordinates. Active subordinates displayed significantly more flight-behaviour than passive subordinates. Dominant intruders showed significantly higher post-stress levels of corticosterone than subordinates, which did not differ from control mice, which experienced five minutes of novel-cage exposure. Comparing all three behavioural phenotypes we found the lowest corticosterone levels in active subordinates. CONCLUSION: Social state significantly affects the HPA-axis response to acute social stressors.
Authors:
Belinda Pletzer; Wolfgang Klimesch; Karin Oberascher-Holzinger; Hubert H Kerschbaum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  28     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  585-90     Citation Subset:  IM    
Affiliation:
Department of Cell Biology, Paris-Lodron-University Salzburg, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Psychological / physiology*
Aggression / physiology*
Animals
Corticosterone / blood*
Dominance-Subordination*
Hypothalamo-Hypophyseal System / physiology
Male
Mice
Mice, Inbred BALB C
Social Environment
Stress, Psychological / blood*,  etiology
Territoriality
Chemical
Reg. No./Substance:
50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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