Document Detail

Corticosterone response in a resident-intruder-paradigm depends on social state and coping style in adolescent male Balb-C mice.
MedLine Citation:
PMID:  17984949     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Social stressors modulate the hypothalamic-pituitary-adrenal axis in rodents. However, reports on the association between corticosterone level and behavioural responses to the stressor are ambivalent. This may depend on the experimental paradigm, species- and strain-differences, duration of exposure to the stressor, but also on using either the social state (dominant or subordinate) or the coping style (proactive or passive) of an animal to correlate the corticosterone level with. DESIGN AND SETTING: We used male Balb-C mice in a resident-intruder paradigm. Adolescent intruders (aged five to eight weeks) were transferred into the cage of an adult resident (aged about four month) for five minutes. The interactions were video-taped for behavioural analysis. Ten minutes after the encounters, intruders were sacrificed and blood samples were collected. RESULTS: Dominant intruders showed offensive behaviours (attack, chase, tail tracking) and won most of the fights, whereas subordinate intrudes showed mainly submissive behaviours (flight, freezing) and were further classified into active and passive subordinates. Active subordinates displayed significantly more flight-behaviour than passive subordinates. Dominant intruders showed significantly higher post-stress levels of corticosterone than subordinates, which did not differ from control mice, which experienced five minutes of novel-cage exposure. Comparing all three behavioural phenotypes we found the lowest corticosterone levels in active subordinates. CONCLUSION: Social state significantly affects the HPA-axis response to acute social stressors.
Belinda Pletzer; Wolfgang Klimesch; Karin Oberascher-Holzinger; Hubert H Kerschbaum
Related Documents :
23049809 - The social brain: transcriptome assembly and characterization of the hippocampus from a...
18421769 - Male reproductive skew, paternal relatedness, and female social relationships.
12732259 - Differential effects of intraspecific interactions on the striatal dopamine system in s...
23001829 - Sangiovese and its offspring in southern italy.
22626789 - Developmental plasticity in metabolic rates reinforces morphological plasticity in resp...
19019779 - An infanticide attempt by a free-roaming feral stallion (equus caballus).
23155719 - Social capital, opportunity, and school-based victimization.
16260039 - Childhood sexual abuse, social support, and psychological outcomes: a loss framework.
19687119 - Living with ankylosing spondylitis: the patient's perspective.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  28     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  585-90     Citation Subset:  IM    
Department of Cell Biology, Paris-Lodron-University Salzburg, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptation, Psychological / physiology*
Aggression / physiology*
Corticosterone / blood*
Hypothalamo-Hypophyseal System / physiology
Mice, Inbred BALB C
Social Environment
Stress, Psychological / blood*,  etiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Depression, prolactin and dissociated mind.
Next Document:  Controversial opinions on the role of cocaine and amphetamine-regulated transcript (CART) in prolact...