Document Detail

Corticosterone-regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol A.
MedLine Citation:
PMID:  20219646     Owner:  NLM     Status:  MEDLINE    
The estrogen-mimicking endocrine disrupter bisphenol A (BPA) which is used in the manufacture of plastic and epoxy resins, is one of the world's most heavily produced synthetic chemicals. BPA is detected in animal tissues, and its bio-accumulation has shown to be higher in the fetus than the mother. Exposure to doses below the daily safe limit has been reported to affect the sexual differentiation of the brain and modify the behavior of the exposed rodent offspring. The aim of the present study was to investigate in the rat the possible organizational effects of low BPA exposure on glucocorticoid-regulated responses. Female breeders were exposed to 40 microg/kg b.w. BPA daily throughout pregnancy and lactation. Plasma corticosterone levels and the two types of hippocampal corticosteroid receptors (GR and MR) were determined in mid-adolescent offspring under basal conditions and following a Y-maze task. BPA treated females had higher corticosterone levels than control females and BPA males and lower GR levels than BPA males, under basal conditions. Following the mildly stressful experience of Y-maze, corticosterone levels were increased in BPA-treated animals of both sexes, compared to the controls. GR levels were also increased in BPA-treated females compared to males. No effect of BPA was observed on MR levels, whereas the Y-maze experience significantly decreased receptors' levels in both female groups. The animals' performance in the task was also evaluated. BPA exposure significantly impaired the spatial recognition memory in both sexes, and modified the behavioural coping in a sex-dependent manner. Female BPA-treated offspring exhibited increased "anxiety-like" behaviour and dramatic loss of exploration attitude during the task, in comparison to males. This study provides for the first time evidence that corticosterone and its actions in the brain are sensitive to the programming effects of BPA at a dose below the currently acceptable daily intake.
A Poimenova; E Markaki; C Rahiotis; E Kitraki
Related Documents :
14980386 - Long-term effects on cortical glutamate release induced by prenatal exposure to the can...
6822256 - Ultrastructural evidence of long-lasting cerebellar degeneration after early exposure t...
7579916 - Testicular alterations in rats due to gestational and early lactational administration ...
2792976 - Effects of ivermectin on reproduction and neonatal toxicity in rats.
10684446 - Urinary nitrotyrosine content as a marker of peroxynitrite-induced tolerance to organic...
16039786 - Amygdalar vasopressin mrna increases in acute cocaine withdrawal: evidence for opioid r...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-26
Journal Detail:
Title:  Neuroscience     Volume:  167     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  741-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Department of Operative Dentistry, School of Dentistry, University of Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptation, Psychological / drug effects,  physiology
Anxiety / chemically induced,  metabolism,  physiopathology
Brain / drug effects*,  metabolism,  physiopathology
Corticosterone / agonists*,  metabolism
Dose-Response Relationship, Drug
Endocrine Disruptors / toxicity*
Environmental Exposure / adverse effects*
Estrogens, Non-Steroidal / toxicity
Exploratory Behavior / drug effects,  physiology
Hippocampus / drug effects,  metabolism,  physiopathology
Hypothalamo-Hypophyseal System / drug effects,  physiopathology
Maze Learning / drug effects,  physiology
Memory Disorders / chemically induced,  metabolism,  physiopathology
Neurosecretory Systems / drug effects,  metabolism,  physiopathology
Phenols / toxicity*
Pituitary-Adrenal System / drug effects,  physiopathology
Prenatal Exposure Delayed Effects / chemically induced*,  metabolism,  physiopathology
Rats, Wistar
Receptors, Steroid / drug effects,  metabolism
Sex Characteristics
Reg. No./Substance:
0/Endocrine Disruptors; 0/Estrogens, Non-Steroidal; 0/Phenols; 0/Receptors, Steroid; 50-22-6/Corticosterone; 80-05-7/bisphenol A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Altered expression of type 1 inositol 1,4,5-trisphosphate receptor in the Ngsk Prnp deficient mice.
Next Document:  Exercise and time-dependent benefits to learning and memory.