| Corticosteroids and radiation mucositis in head and neck cancer. A double-blind placebo-controlled randomized trial. | |
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MedLine Citation:
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PMID: 9683361 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with head and neck cancer were randomized in a double-blind manner to receive 40 mg/day prednisone (n = 32) or placebo (n = 34). The prescribed daily tumour dose was 1.6 Gy twice daily with an interfraction interval of > or =6 h. Treatment interruptions were at the discretion of the radiation oncologists. The primary study end-point was the total duration of treatment. A mean 4.4 day reduction was observed in the total elapsed treatment duration for the prednisone arm, 34.3 versus 29.9 days (P = 0.013), which paralleled a significantly lower median total tumour and biologically effective dose (BED) Gy10 in this arm. A trend favouring shorter treatment interruptions in the prednisone arm was also found, but not a reduction in the intensity or duration of mucositis. |
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Authors:
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J H Leborgne; F Leborgne; E Zubizarreta; B Ortega; J Mezzera |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: 47 ISSN: 0167-8140 ISO Abbreviation: Radiother Oncol Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-09-24 Completed Date: 1998-09-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 145-8 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Instituto de Radiología y Centro de Lucha contra el Cáncer, Hospital Pereira Rossell, Montevideo, Uruguay. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / radiotherapy* Dose Fractionation Double-Blind Method Female Glucocorticoids / therapeutic use* Head and Neck Neoplasms / radiotherapy* Humans Male Middle Aged Mucous Membrane / radiation effects* Prednisone / therapeutic use* Radiation Injuries / prevention & control* Radiotherapy Dosage |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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