Document Detail

Corticosteroids in chronic bronchitis and pulmonary emphysema.
MedLine Citation:
PMID:  344009     Owner:  NLM     Status:  MEDLINE    
Chronic bronchitis and emphysema (chronic obstructive pulmonary disease [COPD]) represent a major health problem in this country. Corticosteroids have provided an important advance in the management of bronchial asthma, but the role of these drugs in the therapy for COPD has not been defined clearly. To gain further insight into this problem, an overview of the pharmacologic properties and mechanisms of action of corticosteroids on the cellular systems of the lung and a critical analysis of the 17 studies evaluating the efficacy of therapy with corticosteroids in COPD were done. There are several theoretic reasons why corticosteroids might be useful in treating COPD; however the majority of studies have not demonstrated a positive effect, yet individual patients have attained marked improvement. An objectively monitored, finite trial of therapy with corticosteroids in the patient with COPD who has worsening symptoms is warranted, as the benefit is high in responsive individuals and the risk is low in nonresponders.
S A Sahn
Related Documents :
19953349 - Nebulized formoterol provides added benefits to tiotropium treatment in chronic obstruc...
16608929 - A randomized controlled trial on office spirometry in asthma and copd in standard gener...
3675139 - Progressive neuropsychologic impairment and hypoxemia. relationship in chronic obstruct...
24339179 - Effect of certolizumab pegol on multiple facets of psoriatic arthritis as reported by p...
24225439 - Trauma and psychological distress observed in journalists: a comparison of israeli jour...
12725879 - Meaningful effect size and patterns of response of the transition dyspnea index.
20010909 - Evaluation of the physical activity scale for individuals with physical disabilities in...
18466269 - An open-label, multicenter, flexible dose study to evaluate the efficacy and safety of ...
7369409 - Dialysis for schizophrenia: review of clinical trials and implications for further rese...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Chest     Volume:  73     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-05-17     Completed Date:  1978-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Betamethasone / therapeutic use
Bronchitis / drug therapy*
Chronic Disease
Cortisone / therapeutic use
Glucocorticoids / therapeutic use*
Prednisolone / therapeutic use
Prednisone / therapeutic use
Pulmonary Emphysema / drug therapy*
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone; 50-24-8/Prednisolone; 53-03-2/Prednisone; 53-06-5/Cortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The validity of determinations of pulmonary wedge pressure during mechanical ventilation.
Next Document:  Deposits of immunoglobulin and complement in the pulmonary tissue of patients with "heroin lung".