Document Detail

Corticosteroids in chronic bronchitis and pulmonary emphysema.
MedLine Citation:
PMID:  344009     Owner:  NLM     Status:  MEDLINE    
Chronic bronchitis and emphysema (chronic obstructive pulmonary disease [COPD]) represent a major health problem in this country. Corticosteroids have provided an important advance in the management of bronchial asthma, but the role of these drugs in the therapy for COPD has not been defined clearly. To gain further insight into this problem, an overview of the pharmacologic properties and mechanisms of action of corticosteroids on the cellular systems of the lung and a critical analysis of the 17 studies evaluating the efficacy of therapy with corticosteroids in COPD were done. There are several theoretic reasons why corticosteroids might be useful in treating COPD; however the majority of studies have not demonstrated a positive effect, yet individual patients have attained marked improvement. An objectively monitored, finite trial of therapy with corticosteroids in the patient with COPD who has worsening symptoms is warranted, as the benefit is high in responsive individuals and the risk is low in nonresponders.
S A Sahn
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Chest     Volume:  73     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-05-17     Completed Date:  1978-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  AIM; IM    
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MeSH Terms
Betamethasone / therapeutic use
Bronchitis / drug therapy*
Chronic Disease
Cortisone / therapeutic use
Glucocorticoids / therapeutic use*
Prednisolone / therapeutic use
Prednisone / therapeutic use
Pulmonary Emphysema / drug therapy*
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone; 50-24-8/Prednisolone; 53-03-2/Prednisone; 53-06-5/Cortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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