Document Detail


Corticosteroids for enhanced fetal lung maturation in patients with HELLP syndrome: impact on neonates.
MedLine Citation:
PMID:  8216108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was undertaken to determine retrospectively, in women with the HELLP syndrome, the perinatal effects of corticosteroid administration for promotion of fetal lung maturity. Twenty-seven of 427 women with the HELLP syndrome treated between 1980 and 1991 received a full course of steroids prior to preterm delivery. They were compared to 27 control patients with the HELLP syndrome matched for maternal age, severity of disease, gestational age, race, and sex of the fetus. Respiratory distress requiring mechanical ventilation occurred in 13 of 27 neonates who received steroid administration and in 23 of 27 who did not receive steroids (p < 0.001). The average stay in the neonatal intensive care unit was 29.8 +/- 50.6 days for the steroid-treated group and 45.2 +/- 35.3 days for the group without steroid use (p = NS). The incidence of neonatal deaths, intraventricular haemorrhage type III and IV, necrotizing enterocolitis, and retrolental fibroplasia was greater in the control group but the difference was not statistically significant.
Authors:
E F Magann; G R Graves; W E Roberts; P G Blake; J C Morrison; J N Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  33     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-10-29     Completed Date:  1993-10-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505.
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MeSH Terms
Descriptor/Qualifier:
Dexamethasone / pharmacology,  therapeutic use*
Female
Fetal Organ Maturity / drug effects
HELLP Syndrome / classification,  drug therapy*
Hospitalization
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / prevention & control*
Lung / drug effects,  embryology*
Pregnancy
Retrospective Studies
Chemical
Reg. No./Substance:
50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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