Document Detail

Corticosteroid therapy does not alter the threshold for contraction-induced injury in dystrophic (mdx) mouse diaphragm.
MedLine Citation:
PMID:  9486869     Owner:  NLM     Status:  MEDLINE    
The effects of methylprednisolone therapy on the susceptibility of dystrophin-deficient myofibers to contraction-induced injury were evaluated in the mdx mouse diaphragm model of Duchenne dystrophy. Mdx myofibers were abnormally vulnerable to injury induced by high-stress eccentric contractions. However, methylprednisolone therapy did not significantly alter the degree of contraction-induced injury. These data suggest that beneficial effects of corticosteroid therapy in Duchenne dystrophy are unlikely to be related to a change in the threshold for contraction-induced myofiber damage.
L Yang; J Luo; B J Petrof
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  21     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-03-13     Completed Date:  1998-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  394-7     Citation Subset:  IM    
Respiratory Division, Royal Victoria Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use*
Analysis of Variance
Methylprednisolone / therapeutic use*
Mice, Inbred C57BL
Mice, Inbred mdx
Muscle Contraction / drug effects,  physiology*
Muscle, Skeletal / drug effects,  injuries*,  pathology
Muscular Dystrophy, Animal / drug therapy*,  physiopathology*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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