Document Detail

Corticosteroid-mediated programming and the pathogenesis of obesity and diabetes.
MedLine Citation:
PMID:  20117209     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies have shown that low birthweight is associated with increased risk of development of diabetes and obesity in later life. Over-exposure of the developing fetus to glucocorticoids is one of the major hypotheses that has been proposed to explain this association. In animal models, a range of manipulations that increase fetal glucocorticoid load, 'programme' permanent changes in glucose and insulin metabolism and adiposity. This may be mediated by alterations in regulation of the hypothalamic-pituitary-adrenal (HPA) axis. In humans, low birthweight is associated with increased circulating glucocorticoid levels, and an increased cortisol response to physiological and psychosocial stressors, in child- and adulthood. This activation of the HPA axis is also associated with increased risk of development of diabetes and obesity in later life.
Rebecca M Reynolds
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-02-01
Journal Detail:
Title:  The Journal of steroid biochemistry and molecular biology     Volume:  122     ISSN:  1879-1220     ISO Abbreviation:  J. Steroid Biochem. Mol. Biol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015483     Medline TA:  J Steroid Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.
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MeSH Terms
Diabetes Mellitus / chemically induced*
Fetal Development / physiology
Glucocorticoids / metabolism*,  poisoning*
Glucose / metabolism
Hypothalamo-Hypophyseal System / embryology*,  physiology
Infant, Low Birth Weight / physiology
Infant, Newborn
Insulin / metabolism
Obesity / chemically induced*
Pituitary-Adrenal System / physiology*
Reg. No./Substance:
0/Glucocorticoids; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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