| Corticosteroid-mediated programming and the pathogenesis of obesity and diabetes. | |
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MedLine Citation:
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PMID: 20117209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological studies have shown that low birthweight is associated with increased risk of development of diabetes and obesity in later life. Over-exposure of the developing fetus to glucocorticoids is one of the major hypotheses that has been proposed to explain this association. In animal models, a range of manipulations that increase fetal glucocorticoid load, 'programme' permanent changes in glucose and insulin metabolism and adiposity. This may be mediated by alterations in regulation of the hypothalamic-pituitary-adrenal (HPA) axis. In humans, low birthweight is associated with increased circulating glucocorticoid levels, and an increased cortisol response to physiological and psychosocial stressors, in child- and adulthood. This activation of the HPA axis is also associated with increased risk of development of diabetes and obesity in later life. |
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Authors:
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Rebecca M Reynolds |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-02-01 |
Journal Detail:
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Title: The Journal of steroid biochemistry and molecular biology Volume: 122 ISSN: 1879-1220 ISO Abbreviation: J. Steroid Biochem. Mol. Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9015483 Medline TA: J Steroid Biochem Mol Biol Country: England |
Other Details:
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Languages: eng Pagination: 3-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom. R.Reynolds@ed.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus / chemically induced* Female Fetal Development / physiology Fetus Glucocorticoids / metabolism*, poisoning* Glucose / metabolism Humans Hypothalamo-Hypophyseal System / embryology*, physiology Infant, Low Birth Weight / physiology Infant, Newborn Insulin / metabolism Obesity / chemically induced* Pituitary-Adrenal System / physiology* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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