Document Detail

Corticosteroid-binding globulin in preterm infants in an intensive care unit.
MedLine Citation:
PMID:  8582714     Owner:  NLM     Status:  MEDLINE    
Blood concentration of corticosteroid-binding globulin (CBG) was measured in 85 preterm (24-36 weeks of gestational age) infants over the first 6 weeks of postnatal life. CBG concentrations directly correlated to gestational age and postnatal age in the first week of life. There was a significant increase in CBG values over the first 6 weeks such that mean values at weeks 4 through 6 were significantly greater than values at weeks 1 and 2. Postnatal CBG values were significantly lower in infants who had pulmonary disease during week 1 (p = 0.001). In summary, CBG values were directly correlated to gestational and postnatal age, and negatively correlated to acute illness. We speculate that the lower CBG values with lung disease may reflect an ongoing inflammatory response.
S M Scott; L Wells
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hormone research     Volume:  44     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  218-21     Citation Subset:  IM    
Department of Pediatrics, Children's Hospital of New Mexico, University of New Mexico School of Medicine, Albuquerque 87123-5311, USA.
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MeSH Terms
Aging / blood
Analysis of Variance
Gestational Age
Infant, Newborn
Infant, Premature / blood*
Infant, Premature, Diseases / blood*
Intensive Care Units, Neonatal
Lung Diseases / metabolism
Regression Analysis
Transcortin / metabolism*
Grant Support
5M01RR00997-14-18/RR/NCRR NIH HHS
Reg. No./Substance:

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