| Corticosteroid therapy and secondary elevated intraocular pressure in patients with Fuchs heterochromic cyclitis and idiopathic chronic anterior uveitis | |
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MedLine Citation:
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PMID: 20217637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Due to different influences on anterior chamber angle structures, corticosteroids have a significant impact on secondary elevated intraocular pressure. This study examines the influence of corticosteroid therapy on the incidence of secondary elevated intraocular pressure in patients with Fuchs heterochromic cyclitis (FHC) and chronic anterior uveitis. MATERIALS AND METHODS: Retrospective chart analyses of patients undergoing topical and systemic corticosteroid therapy were carried out. RESULTS: Overall, data of 54 FHC and 49 CAU patients were analysed. Patients did not differ with respect to age, gender distribution and follow-up period. Seventeen (37 %) of the FHC patients and eight (18 %) of the CAU patients had secondary elevated intraocular pressure (p = 0.08). Number of months with topical therapy (54 vs. 20 months, p = 0.025) and number of months multiplicated with the frequency of topical maintenance therapy (158 vs. 61 p = 0.027) were significantly higher in the FHC patients. Only in the FHC group was an association with age (OR 1.16; 95 % CI 1.03 - 1.2; p = 0,006) and in the CAU group with the number of topical corticosteroid therapies (OR 1.15; 95 % CI 0.99 - 1.34; p = 0.03) evident in the multivariate analysis. CONCLUSIONS: Pathomechanisms, resulting in secondary elevated intraocular pressure in patients with FHC and CAU, must be different as only in CAU patients was an association to corticosteroid therapy found. |
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Authors:
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C Heinz; B Zureck-Imhoff; M Roesel; A Heiligenhaus |
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Publication Detail:
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Type: English Abstract; Journal Article Date: 2010-03-09 |
Journal Detail:
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Title: Klinische Monatsblätter für Augenheilkunde Volume: 227 ISSN: 1439-3999 ISO Abbreviation: Klin Monbl Augenheilkd Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0014133 Medline TA: Klin Monbl Augenheilkd Country: Germany |
Other Details:
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Languages: ger Pagination: 413-7 Citation Subset: IM |
Affiliation:
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Augenabteilung, St. Franziskus Hospital, Münster, Germany. carsten.heinz@uveitis-zentrum.de |
Vernacular Title:
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Kortikosteroidtherapie und sekundäre Augeninnendruckerhöhung bei Fuchs-Heterochromiezyklitis und idiopathischer chronischer anteriorer Uveitis. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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administration & dosage*,
adverse effects* Chronic Disease Female Fuchs' Endothelial Dystrophy / complications, drug therapy* Humans Intraocular Pressure / drug effects Male Middle Aged Ocular Hypertension / chemically induced*, diagnosis Retrospective Studies Treatment Outcome Uveitis / complications, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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