| Corticonigral degeneration with neuronal achromasia. A clinicopathologic study of two cases. | |
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MedLine Citation:
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PMID: 1700809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe the clinical and neuropathological features of two patients having corticonigral degeneration with neuronal achromasia (CND). Both patients had cognitive decline and movement disorders. Magnetic resonance (MR) scans showed cortical atrophy, which in one case was most prominent in the parasylvian region, and ventricular enlargement in both cases. Neuropathological examination revealed swollen achromasic neurons within the cerebral cortex and marked neuronal loss in the substantia nigra. No Pick bodies, Lewy bodies, histologic changes of Alzheimer's disease, or spongiform change were present in either case. The diagnosis of CND should be considered in patients with complex movement disorders, with or without abnormalities in cognitive function. |
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Authors:
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C F Lippa; T W Smith; N Fontneau |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 98 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1991-01-03 Completed Date: 1991-01-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 301-10 Citation Subset: IM |
Affiliation:
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Department of Pathology (Neuropathology) University of Massachusetts Medical Center, Worcester 01655. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain Diseases / diagnosis, metabolism, pathology Cerebral Cortex / metabolism, pathology* Humans Magnetic Resonance Imaging Male Microscopy, Electron Nerve Degeneration Neurons / pathology* Staining and Labeling Substantia Nigra / metabolism, pathology* |
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