Document Detail

Corticonigral degeneration with neuronal achromasia. A clinicopathologic study of two cases.
MedLine Citation:
PMID:  1700809     Owner:  NLM     Status:  MEDLINE    
We describe the clinical and neuropathological features of two patients having corticonigral degeneration with neuronal achromasia (CND). Both patients had cognitive decline and movement disorders. Magnetic resonance (MR) scans showed cortical atrophy, which in one case was most prominent in the parasylvian region, and ventricular enlargement in both cases. Neuropathological examination revealed swollen achromasic neurons within the cerebral cortex and marked neuronal loss in the substantia nigra. No Pick bodies, Lewy bodies, histologic changes of Alzheimer's disease, or spongiform change were present in either case. The diagnosis of CND should be considered in patients with complex movement disorders, with or without abnormalities in cognitive function.
C F Lippa; T W Smith; N Fontneau
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  98     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-03     Completed Date:  1991-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  301-10     Citation Subset:  IM    
Department of Pathology (Neuropathology) University of Massachusetts Medical Center, Worcester 01655.
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MeSH Terms
Brain Diseases / diagnosis,  metabolism,  pathology
Cerebral Cortex / metabolism,  pathology*
Magnetic Resonance Imaging
Microscopy, Electron
Nerve Degeneration
Neurons / pathology*
Staining and Labeling
Substantia Nigra / metabolism,  pathology*

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