| Cortico-cortical projections in mouse visual cortex are functionally target specific. | |
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MedLine Citation:
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PMID: 23292681 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Neurons in primary sensory cortex have diverse response properties, whereas higher cortical areas are specialized. Specific connectivity may be important for areal specialization, particularly in the mouse, where neighboring neurons are functionally diverse. To examine whether higher visual areas receive functionally specific input from primary visual cortex (V1), we used two-photon calcium imaging to measure responses of axons from V1 arborizing in three areas with distinct spatial and temporal frequency preferences. We found that visual preferences of presynaptic boutons in each area were distinct and matched the average preferences of recipient neurons. This specificity could not be explained by organization within V1 and instead was due to both a greater density and greater response amplitude of functionally matched boutons. Projections from a single layer (layer 5) and from secondary visual cortex were also matched to their target areas. Thus, transmission of specific information to downstream targets may be a general feature of cortico-cortical communication. |
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Authors:
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Lindsey L Glickfeld; Mark L Andermann; Vincent Bonin; R Clay Reid |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-06 |
Journal Detail:
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Title: Nature neuroscience Volume: - ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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