Document Detail


Cortico-cortical projections in mouse visual cortex are functionally target specific.
MedLine Citation:
PMID:  23292681     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurons in primary sensory cortex have diverse response properties, whereas higher cortical areas are specialized. Specific connectivity may be important for areal specialization, particularly in the mouse, where neighboring neurons are functionally diverse. To examine whether higher visual areas receive functionally specific input from primary visual cortex (V1), we used two-photon calcium imaging to measure responses of axons from V1 arborizing in three areas with distinct spatial and temporal frequency preferences. We found that visual preferences of presynaptic boutons in each area were distinct and matched the average preferences of recipient neurons. This specificity could not be explained by organization within V1 and instead was due to both a greater density and greater response amplitude of functionally matched boutons. Projections from a single layer (layer 5) and from secondary visual cortex were also matched to their target areas. Thus, transmission of specific information to downstream targets may be a general feature of cortico-cortical communication.
Authors:
Lindsey L Glickfeld; Mark L Andermann; Vincent Bonin; R Clay Reid
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-06
Journal Detail:
Title:  Nature neuroscience     Volume:  16     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-03-22     Revised Date:  2013-12-20    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / metabolism
Brain Mapping*
Calcium
Dexamethasone / metabolism
Female
Green Fluorescent Proteins / genetics
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Net / physiology*
Neurons / physiology*
Photic Stimulation
Psychophysics
Retinol-Binding Proteins, Plasma / genetics
Rhodamines / metabolism
Visual Cortex / physiology*
Visual Pathways / physiology*
Grant Support
ID/Acronym/Agency:
R01 EY010115/EY/NEI NIH HHS; R01 EY010115/EY/NEI NIH HHS; R01 EY018742/EY/NEI NIH HHS; R01 EY018742/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Rbp4 protein, mouse; 0/Retinol-Binding Proteins, Plasma; 0/Rhodamines; 0/enhanced green fluorescent protein; 147336-22-9/Green Fluorescent Proteins; 60311-02-6/sulforhodamine 101; 7S5I7G3JQL/Dexamethasone; SY7Q814VUP/Calcium
Comments/Corrections

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