Document Detail


Cortico-cortical networks in patients with ideomotor apraxia as revealed by EEG coherence analysis.
MedLine Citation:
PMID:  18249498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to determine whether coherent networks which circumvent lesioned cortex are seen in patients with ideomotor apraxia (IMA) while performing tool-use pantomimes. Five normal subjects and five patients with IMA (three patients with corticobasal degeneration and two with left hemisphere stroke) underwent 64-channel EEG recording while performing three tool-use pantomimes with their left hand in a self-paced manner. Beta band (20-22 Hz) coherence indicates that normal subjects have a dominant left hemisphere network responsible for praxis preparation, which was absent in patients. Corticobasal degeneration patients showed significant coherence increase between left parietal-right premotor areas. Left hemisphere stroke patients showed significant coherence increases in a right parietofrontal network. The right hemisphere appears to store useable praxis representations in IMA patients with left hemisphere damage.
Authors:
Lewis A Wheaton; Stephan Bohlhalter; Guido Nolte; Hiroshi Shibasaki; Noriaki Hattori; Esteban Fridman; Sherry Vorbach; Jordan Grafman; Mark Hallett
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Intramural     Date:  2008-01-12
Journal Detail:
Title:  Neuroscience letters     Volume:  433     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-29     Completed Date:  2008-06-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Affiliation:
Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892-1428, United States.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apraxia, Ideomotor / pathology*,  physiopathology*
Cerebral Cortex / physiopathology*
Electroencephalography*
Functional Laterality / physiology
Humans
Middle Aged
Nerve Net / physiopathology*
Neurodegenerative Diseases / pathology,  physiopathology
Stroke / pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
Z01 NS002669-23/NS/NINDS NIH HHS
Comments/Corrections
Erratum In:
Neurosci Lett. 2009 Jan 16;449(3):259

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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