Document Detail

Cortical and trabecular bone in the femoral neck both contribute to proximal femur failure load prediction.
MedLine Citation:
PMID:  18661091     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The relative contribution of femoral neck trabecular and cortical bone to proximal femur failure load is unclear.
OBJECTIVES: Our primary objective was to determine whether trabecular bone mineral density (TbBMD) contributes to proximal femur failure load after accounting for total bone size and cortical bone content. Our secondary objective was to describe regional differences in the relationship among cortical bone, trabecular bone, and failure load within a cross-section of the femoral neck.
MATERIALS AND METHODS: We imaged 36 human cadaveric proximal femora using quantitative computed tomography (QCT). We report total bone area (ToA), cortical area (CoA), cortical bone mineral content (CoBMC), and TbBMD measured in the femoral neck cross-section and eight 45 degrees regions. The femora were loaded to failure.
RESULTS AND OBSERVATIONS: Trabecular bone mineral density explained a significant proportion of variance in failure load after accounting for ToA and then either CoBMC or CoA respectively. CoBMC contributed significantly to failure load in all regions of the femoral neck except the posterior region. TbBMD contributed significantly to failure load in all regions of the femoral neck except the inferoanterior, superoposterior, and the posterior regions.
CONCLUSION: Both cortical and trabecular bone make significant contributions to failure load in ex vivo measures of bone strength.
S L Manske; T Liu-Ambrose; D M L Cooper; S Kontulainen; P Guy; B B Forster; H A McKay
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-26
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  20     ISSN:  1433-2965     ISO Abbreviation:  Osteoporos Int     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2010-02-02     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  445-53     Citation Subset:  IM    
UBC Department of Orthopaedics, Centre for Hip Health and Musculoskeletal Research, Vancouver Coastal Health Research Institute, 302-2647 Willow Street, Vancouver, BC V5Z3P1, Canada.
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MeSH Terms
Absorptiometry, Photon
Aged, 80 and over
Bone Density / physiology*
Femur Neck / anatomy & histology,  physiology*,  radiography
Hip Fractures / pathology*,  radiography
Middle Aged
Stress, Mechanical
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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