Document Detail


Cortical thickness and subcortical gray matter reductions in neuropsychiatric systemic lupus erythematosus.
MedLine Citation:
PMID:  20352085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Within systemic lupus erythematosus (SLE) patients can be divided into groups with and without central nervous system involvement, the latter being subcategorized as neuropsychiatric systemic lupus erythematosus (NPSLE). While a number of research groups have investigated NPSLE, there remains a lack of consistent application of this diagnostic criteria within neuroimaging studies. Previous neuroimaging research suggests that SLE patients have reduced subcortical and regional gray matter volumes when compared to controls, and that these group differences may be driven by SLE patients with neuropsychiatric symptoms. The current study sought to compare measures of cortical thickness and subcortical structure volume between NPSLE, SLE, and healthy controls. We hypothesized that patients with NPSLE (N = 21) would have thinner cortex and reduced subcortical gray matter volumes when compared to SLE (N = 16) and control subjects (N = 21). All subjects underwent MRI examinations on a 1.5 Tesla Siemens Sonata scanner. Anatomical reconstruction and segmentation were performed using the FreeSurfer image analysis suite. Cortical and subcortical volumes were extracted from FreeSurfer and analyzed for group differences, controlling for age. The NPSLE group exhibited decreased cortical thickness in clusters of the left frontal and parietal lobes as well as in the right parietal and occipital lobes compared to control subjects. Compared to the SLE group, the NPSLE group exhibited comparable thinning in clusters of the frontal and temporal lobes. Controlling for age, we found that between group effects for subcortical gray matter structures were significant for the thalamus (F = 3.06, p = .04), caudate nucleus (F = 3.19, p = .03), and putamen (F = 4.82, p = .005). These results clarify previous imaging work identifying cortical atrophy in a mixed SLE and NPSLE group, and suggest that neuroanatomical abnormalities are specific to SLE patients diagnosed with neuropsychiatric symptoms. Future work should help elucidate the underlying mechanisms underlying the emerging neurobiological profile seen in NPSLE, as well as clarify the apparent lack of overlap between cortical thinning and functional activation results and other findings pointing to increased functional activation during cognitive tasks.
Authors:
Rex E Jung; Judith M Segall; Rachael G Grazioplene; Clifford Qualls; Wilmer L Sibbitt; Carlos A Roldan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-03-24
Journal Detail:
Title:  PloS one     Volume:  5     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-30     Completed Date:  2011-01-11     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e9302     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, University of New Mexico, Albuquerque, New Mexico, United States of America. rjung@salud.unm.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / pathology,  physiology*
Brain Mapping / methods
Case-Control Studies
Female
Humans
Image Processing, Computer-Assisted
Lupus Vasculitis, Central Nervous System / diagnosis,  physiopathology*
Magnetic Resonance Imaging / methods
Male
Middle Aged
Regression Analysis
Grant Support
ID/Acronym/Agency:
R01HL077422-01A1/HL/NHLBI NIH HHS; UL1 TR000041/TR/NCATS NIH HHS
Comments/Corrections

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