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Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia.
MedLine Citation:
PMID:  21212942     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: The study was conducted to evaluate simultaneously gray matter changes and white matter changes in patients with schizophrenia. METHODS: Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity changes in schizophrenic patients (n = 21) were assessed relative to age-, gender-, and parental socioeconomic status-matched healthy controls (n = 21). We used a newly described semi-automated method (FreeSurfer version 4.5) to determine cortical thickness and gray matter volume and used the tract-based spatial statistics method to evaluate white matter anisotropy and diffusivity. RESULTS: Schizophrenic patients showed a significant decrease in hippocampal volume compared with healthy controls. No significant thickness deficits or anisotropy and diffusivity changes were found in schizophrenic patients compared with healthy controls. Stepwise multivariate analysis revealed that hippocampal volume was positively related to duration of illness in schizophrenic patients. CONCLUSION: Our results suggest that hippocampal volume is smaller in schizophrenic patients compared with healthy controls and that progressive hippocampal volume loss occurs in the early course of illness in schizophrenic patients but not in the more chronic stages.
Authors:
Mizuho Murakami; Hidemasa Takao; Osamu Abe; Hidenori Yamasue; Hiroki Sasaki; Wataru Gonoi; Yosuke Takano; Kunio Takei; Kiyoto Kasai; Kuni Ohtomo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-7
Journal Detail:
Title:  Neuroradiology     Volume:  -     ISSN:  1432-1920     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, tanomizu@gmail.com.
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