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Cortical thickness at the time of the initial attack in two patients with paediatric relapsing-remitting multiple sclerosis.
MedLine Citation:
PMID:  24393840     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system with a low incidence in the paediatric population; cortical atrophy is often striking, even in the early stages of the disease. Evidence of cortical thinning in childhood MS is scant.
AIMS: This study aimed to assess cortical thickness in paediatric patients during the initial attack of remitting-relapsing MS.
METHODS: We report two cases of remitting-relapsing MS, with initial attacks at 12 and 16 years of age. We analysed brain cortical thickness (CTh) in these patients and compared these data to the CTh of a control group comprised of six 12-year-old females and six 16-year-old males.
RESULTS: Both cases exhibited a total brain CTh significantly below that of the control group. This difference was also observed when analysing the CTh of all lobes except the left parietal lobe in one of the cases.
CONCLUSIONS: Cortical atrophy is already present at the time of onset of MS. Studies with larger patient populations that have a more homogenous clinical presentation could identify the time of onset of cortical atrophy and use this parameter as a prognostic and/or treatment marker of MS.
Authors:
Alberto Fernández-Jaén; Daniel Martín Fernández-Mayoralas; Ana Laura Fernández-Perrone; Mar Jiménez de la Peña; Manuel Recio Rodríguez; Beatriz Calleja-Pérez; Nuria Muñoz Jareño; Rafael Arroyo; Jacobo Albert
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-24
Journal Detail:
Title:  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society     Volume:  -     ISSN:  1532-2130     ISO Abbreviation:  Eur. J. Paediatr. Neurol.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715169     Medline TA:  Eur J Paediatr Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
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