Document Detail


Cortical stimulation study of the role of rhinal cortex in déjà vu and reminiscence of memories.
MedLine Citation:
PMID:  15365137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the role of perirhinal (PC) and entorhinal cortices (EC) in dreamy state symptoms (déjà vu and reminiscence of scenes). These phenomena have been attributed to functional alteration of memory networks supported by the medial temporal lobes, principally involving the amygdala and hippocampus. The role of sub-hippocampal structures (EC and PC) in inducing these phenomena has not previously been addressed. METHODS: The authors studied the symptoms evoked by direct electrical stimulations of PC and EC in comparison with those obtained after stimulation of the amygdala and hippocampus. Stimulations were performed in a group of 24 patients with epilepsy, during stereoelectroencephalographic (SEEG) recordings in the setting of presurgical evaluation. All patients had electrodes that sampled the rhinal cortices, amygdala, and hippocampus. RESULTS: A total of 280 stimulations were analyzed. Entorhinal and perirhinal stimulations induced classic mesial temporal lobe responses (emotional, dysautonomic) but also more specific responses, particularly the déjà vu phenomenon and reminiscence of scenes. Such déjà vu or déjà vécu type responses were produced proportionately more often by stimulation of the EC than by stimulation of the amygdala and hippocampus. In particular, déjà vu was associated with stimulation of the EC and reminiscence of memories with PC stimulation. CONCLUSION: This study strongly suggests that experiential symptoms are largely dependent upon functional modification of the physiology of the rhinal cortices.
Authors:
F Bartolomei; E Barbeau; M Gavaret; M Guye; A McGonigal; J Régis; P Chauvel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  63     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-14     Completed Date:  2005-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  858-64     Citation Subset:  AIM; IM    
Affiliation:
Service de Neurophysiologie Clinique, CHU Timone-264 Rue st Pierre, 13005-Marseille, France. fbartolo@medecine.univ-mrs.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Amygdala / physiology
Deja Vu*
Dysarthria / physiopathology
Electric Stimulation
Electrodes, Implanted
Electroencephalography
Entorhinal Cortex / physiology*
Epilepsies, Partial / physiopathology
Fear / physiology
Female
Headache / etiology,  physiopathology
Hippocampus / physiology
Humans
Male
Mental Recall / physiology*
Paresthesia / physiopathology
Temporal Lobe / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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