Document Detail


Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia.
MedLine Citation:
PMID:  8099795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A unique model of DA system regulation is presented, in which tonic steady-state DA levels in the ECF act to down-regulate the response of the system to pulsatile DA released by DA cell action potential generation. This type of regulation is similar in many respects to the phenomenon proposed to mediate the action of norepinephrine on target neurons; i.e., an increase in the "signal-to-noise" ratio as measured by postsynaptic cell firing (Freedman et al., 1977; Woodward et al., 1979). However, in this model the signal and the noise are neurochemical rather than electrophysiological. Furthermore, the "noise" (tonic DA in the ECF) actually down-regulates the "signal" (phasic DA release) directly, and thereby provides a "signal" of its own that affects the system over a longer time-course. Therefore, the difference between signal and noise may also depend on the time frame under which such determinations are made.
Authors:
A A Grace
Related Documents :
15975975 - Direct inhibition of substantia gelatinosa neurones in the rat spinal cord by activatio...
8891275 - Evidence that d2 receptor-mediated activation of hypothalamic tuberoinfundibular dopami...
8845745 - Dopamine receptor alterations correlate with increased gaba levels in adult rat neostri...
2530755 - Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain.
15127085 - The effects of dizocilpine and phencyclidine on prepulse inhibition of the acoustic sta...
2865705 - Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vit...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of neural transmission. General section     Volume:  91     ISSN:  0300-9564     ISO Abbreviation:  J. Neural Transm. Gen. Sect.     Publication Date:  1993  
Date Detail:
Created Date:  1993-07-16     Completed Date:  1993-07-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9002201     Medline TA:  J Neural Transm Gen Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  111-34     Citation Subset:  IM    
Affiliation:
Department of Behavioral Neuroscience, University of Pittsburgh, PA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Afferent Pathways
Animals
Antipsychotic Agents / pharmacology
Cerebral Cortex / physiology*
Cognition / physiology
Corpus Striatum / physiology
Disease Models, Animal
Dopamine / physiology*
Dopamine Antagonists
Extracellular Space / metabolism
Feedback
Humans
Models, Neurological*
Models, Psychological
Nucleus Accumbens / physiology
Rats
Receptors, Dopamine / drug effects,  physiology
Schizophrenia / physiopathology*
Schizophrenic Psychology
Synapses / metabolism
Synaptic Transmission / drug effects
Grant Support
ID/Acronym/Agency:
MH 42217/MH/NIMH NIH HHS; MH 45156/MH/NIMH NIH HHS; NS 19608/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dopamine Antagonists; 0/Receptors, Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hypertension and a tumor of the glomus jugulare region. Evidence for epinephrine biosynthesis.
Next Document:  Monoamine neurons in aging and Alzheimer's disease.