| Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia. | |
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MedLine Citation:
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PMID: 8099795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A unique model of DA system regulation is presented, in which tonic steady-state DA levels in the ECF act to down-regulate the response of the system to pulsatile DA released by DA cell action potential generation. This type of regulation is similar in many respects to the phenomenon proposed to mediate the action of norepinephrine on target neurons; i.e., an increase in the "signal-to-noise" ratio as measured by postsynaptic cell firing (Freedman et al., 1977; Woodward et al., 1979). However, in this model the signal and the noise are neurochemical rather than electrophysiological. Furthermore, the "noise" (tonic DA in the ECF) actually down-regulates the "signal" (phasic DA release) directly, and thereby provides a "signal" of its own that affects the system over a longer time-course. Therefore, the difference between signal and noise may also depend on the time frame under which such determinations are made. |
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Authors:
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A A Grace |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of neural transmission. General section Volume: 91 ISSN: 0300-9564 ISO Abbreviation: J. Neural Transm. Gen. Sect. Publication Date: 1993 |
Date Detail:
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Created Date: 1993-07-16 Completed Date: 1993-07-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9002201 Medline TA: J Neural Transm Gen Sect Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 111-34 Citation Subset: IM |
Affiliation:
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Department of Behavioral Neuroscience, University of Pittsburgh, PA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Afferent Pathways Animals Antipsychotic Agents / pharmacology Cerebral Cortex / physiology* Cognition / physiology Corpus Striatum / physiology Disease Models, Animal Dopamine / physiology* Dopamine Antagonists Extracellular Space / metabolism Feedback Humans Models, Neurological* Models, Psychological Nucleus Accumbens / physiology Rats Receptors, Dopamine / drug effects, physiology Schizophrenia / physiopathology* Schizophrenic Psychology Synapses / metabolism Synaptic Transmission / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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MH 42217/MH/NIMH NIH HHS; MH 45156/MH/NIMH NIH HHS; NS 19608/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Dopamine Antagonists; 0/Receptors, Dopamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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