Document Detail

Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia.
MedLine Citation:
PMID:  8099795     Owner:  NLM     Status:  MEDLINE    
A unique model of DA system regulation is presented, in which tonic steady-state DA levels in the ECF act to down-regulate the response of the system to pulsatile DA released by DA cell action potential generation. This type of regulation is similar in many respects to the phenomenon proposed to mediate the action of norepinephrine on target neurons; i.e., an increase in the "signal-to-noise" ratio as measured by postsynaptic cell firing (Freedman et al., 1977; Woodward et al., 1979). However, in this model the signal and the noise are neurochemical rather than electrophysiological. Furthermore, the "noise" (tonic DA in the ECF) actually down-regulates the "signal" (phasic DA release) directly, and thereby provides a "signal" of its own that affects the system over a longer time-course. Therefore, the difference between signal and noise may also depend on the time frame under which such determinations are made.
A A Grace
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of neural transmission. General section     Volume:  91     ISSN:  -     ISO Abbreviation:  J. Neural Transm. Gen. Sect.     Publication Date:  1993  
Date Detail:
Created Date:  1993-07-16     Completed Date:  1993-07-16     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9002201     Medline TA:  J Neural Transm Gen Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  111-34     Citation Subset:  IM    
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MeSH Terms
Afferent Pathways
Antipsychotic Agents / pharmacology
Cerebral Cortex / physiology*
Cognition / physiology
Corpus Striatum / physiology
Disease Models, Animal
Dopamine / physiology*
Dopamine Antagonists
Extracellular Space / metabolism
Models, Neurological*
Models, Psychological
Nucleus Accumbens / physiology
Receptors, Dopamine / drug effects,  physiology
Schizophrenia / physiopathology*
Schizophrenic Psychology
Synapses / metabolism
Synaptic Transmission / drug effects
Grant Support
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dopamine Antagonists; 0/Receptors, Dopamine; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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