Document Detail


Cortical localization of temporal lobe language sites in patients with gliomas.
MedLine Citation:
PMID:  7516498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a series of 40 patients undergoing an awake craniotomy for the removal of a glioma of the dominant hemisphere temporal lobe, cortical stimulation mapping was used to localize essential language sites. These sites were localized to distinct temporal lobe sectors and compared with 83 patients without tumors who had undergone language mapping for the treatment of intractable epilepsy. In patients with and without temporal lobe gliomas, the superior temporal gyrus contained significantly more language sites than the middle temporal gyrus. Both patient populations also had language sites anterior to the central sulcus in the superior temporal gyrus (12-16%). The patients without tumors had significantly more language sites in the superior temporal gyrus, compared with the superior temporal gyrus of patients with temporal lobe tumors. Multiple variables were studied for their effect on preoperative and postoperative language deficits and included age, sex, number of language sites, histology, size of the tumor, and the distance of tumor resection margins from the nearest language site. The distance of the resection margin from the nearest language site was the most important variable in determining the improvement in preoperative language deficits, the duration of postoperative language deficits, and whether the postoperative language deficits were permanent. If the distance of the resection margin from the nearest language site was > 1 cm, significantly fewer permanent language deficits occurred. Cortical stimulation mapping for the identification of essential language sites in patients with gliomas of the dominant hemisphere temporal lobe will maximize the extent of tumor resection and minimize permanent language deficits.
Authors:
M M Haglund; M S Berger; M Shamseldin; E Lettich; G A Ojemann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurosurgery     Volume:  34     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-07-20     Completed Date:  1994-07-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  567-76; discussion 576     Citation Subset:  IM    
Affiliation:
Department of Neurological Surgery, University of Washington, Seattle.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anomia / physiopathology
Aphasia / physiopathology
Astrocytoma / physiopathology,  surgery
Brain Mapping / methods*
Brain Neoplasms / physiopathology*,  surgery
Child
Craniotomy
Dominance, Cerebral / physiology*
Electric Stimulation
Epilepsy, Temporal Lobe / physiopathology,  surgery
Female
Ganglioglioma / physiopathology,  surgery
Glioblastoma / physiopathology,  surgery
Glioma / physiopathology*,  surgery
Humans
Language Tests
Male
Middle Aged
Monitoring, Intraoperative / methods*
Oligodendroglioma / physiopathology,  surgery
Postoperative Complications / physiopathology
Psychosurgery
Temporal Lobe / physiopathology*,  surgery
Treatment Outcome
Verbal Behavior / physiology*
Grant Support
ID/Acronym/Agency:
KO8 NS01253-01/NS/NINDS NIH HHS; NINCDS 5 PO NS 17111-05/NS/NINDS NIH HHS; T32NS07144-13/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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