| Cortical localization of temporal lobe language sites in patients with gliomas. | |
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MedLine Citation:
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PMID: 7516498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a series of 40 patients undergoing an awake craniotomy for the removal of a glioma of the dominant hemisphere temporal lobe, cortical stimulation mapping was used to localize essential language sites. These sites were localized to distinct temporal lobe sectors and compared with 83 patients without tumors who had undergone language mapping for the treatment of intractable epilepsy. In patients with and without temporal lobe gliomas, the superior temporal gyrus contained significantly more language sites than the middle temporal gyrus. Both patient populations also had language sites anterior to the central sulcus in the superior temporal gyrus (12-16%). The patients without tumors had significantly more language sites in the superior temporal gyrus, compared with the superior temporal gyrus of patients with temporal lobe tumors. Multiple variables were studied for their effect on preoperative and postoperative language deficits and included age, sex, number of language sites, histology, size of the tumor, and the distance of tumor resection margins from the nearest language site. The distance of the resection margin from the nearest language site was the most important variable in determining the improvement in preoperative language deficits, the duration of postoperative language deficits, and whether the postoperative language deficits were permanent. If the distance of the resection margin from the nearest language site was > 1 cm, significantly fewer permanent language deficits occurred. Cortical stimulation mapping for the identification of essential language sites in patients with gliomas of the dominant hemisphere temporal lobe will maximize the extent of tumor resection and minimize permanent language deficits. |
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Authors:
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M M Haglund; M S Berger; M Shamseldin; E Lettich; G A Ojemann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurosurgery Volume: 34 ISSN: 0148-396X ISO Abbreviation: Neurosurgery Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-07-20 Completed Date: 1994-07-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 567-76; discussion 576 Citation Subset: IM |
Affiliation:
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Department of Neurological Surgery, University of Washington, Seattle. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anomia / physiopathology Aphasia / physiopathology Astrocytoma / physiopathology, surgery Brain Mapping / methods* Brain Neoplasms / physiopathology*, surgery Child Craniotomy Dominance, Cerebral / physiology* Electric Stimulation Epilepsy, Temporal Lobe / physiopathology, surgery Female Ganglioglioma / physiopathology, surgery Glioblastoma / physiopathology, surgery Glioma / physiopathology*, surgery Humans Language Tests Male Middle Aged Monitoring, Intraoperative / methods* Oligodendroglioma / physiopathology, surgery Postoperative Complications / physiopathology Psychosurgery Temporal Lobe / physiopathology*, surgery Treatment Outcome Verbal Behavior / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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KO8 NS01253-01/NS/NINDS NIH HHS; NINCDS 5 PO NS 17111-05/NS/NINDS NIH HHS; T32NS07144-13/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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