| Cortical and limbic activation during viewing of high- versus low-calorie foods. | |
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MedLine Citation:
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PMID: 12948696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the high prevalence of obesity, eating disorders, and weight-related health problems in modernized cultures, the neural systems regulating human feeding remain poorly understood. Therefore, we applied functional magnetic resonance imaging (fMRI) to study the cerebral responses of 13 healthy normal-weight adult women as they viewed color photographs of food. The motivational salience of the stimuli was manipulated by presenting images from three categories: high-calorie foods, low-calorie foods, and nonedible dining-related utensils. Both food categories were associated with bilateral activation of the amygdala and ventromedial prefrontal cortex. High-calorie foods yielded significant activation within the medial and dorsolateral prefrontal cortex, thalamus, hypothalamus, corpus callosum, and cerebellum. Low-calorie foods yielded smaller regions of focal activation within medial orbitofrontal cortex; primary gustatory/somatosensory cortex; and superior, middle, and medial temporal regions. Findings suggest that the amygdala may be responsive to a general category of biologically relevant stimuli such as food, whereas separate ventromedial prefrontal systems may be activated depending on the perceived reward value or motivational salience of food stimuli. |
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Authors:
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William D S Killgore; Ashley D Young; Lisa A Femia; Piotr Bogorodzki; Jadwiga Rogowska; Deborah A Yurgelun-Todd |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: NeuroImage Volume: 19 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-09-01 Completed Date: 2003-10-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 1381-94 Citation Subset: IM |
Affiliation:
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Cognitive Neuroimaging Laboratory, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA. william.killgore@na.amedd.army.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amygdala / physiology Appetite / physiology* Brain Mapping Cerebellum / physiology Cerebral Cortex / physiology* Corpus Callosum / physiology Dominance, Cerebral / physiology Energy Intake / physiology* Female Food* Humans Hypothalamus / physiology Image Processing, Computer-Assisted* Imaging, Three-Dimensional* Limbic System / physiology* Magnetic Resonance Imaging* Motivation Nerve Net / physiology Pattern Recognition, Visual / physiology* Prefrontal Cortex / physiology Reference Values Somatosensory Cortex / physiology Thalamus / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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