Document Detail


Cortical and limbic activation during viewing of high- versus low-calorie foods.
MedLine Citation:
PMID:  12948696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the high prevalence of obesity, eating disorders, and weight-related health problems in modernized cultures, the neural systems regulating human feeding remain poorly understood. Therefore, we applied functional magnetic resonance imaging (fMRI) to study the cerebral responses of 13 healthy normal-weight adult women as they viewed color photographs of food. The motivational salience of the stimuli was manipulated by presenting images from three categories: high-calorie foods, low-calorie foods, and nonedible dining-related utensils. Both food categories were associated with bilateral activation of the amygdala and ventromedial prefrontal cortex. High-calorie foods yielded significant activation within the medial and dorsolateral prefrontal cortex, thalamus, hypothalamus, corpus callosum, and cerebellum. Low-calorie foods yielded smaller regions of focal activation within medial orbitofrontal cortex; primary gustatory/somatosensory cortex; and superior, middle, and medial temporal regions. Findings suggest that the amygdala may be responsive to a general category of biologically relevant stimuli such as food, whereas separate ventromedial prefrontal systems may be activated depending on the perceived reward value or motivational salience of food stimuli.
Authors:
William D S Killgore; Ashley D Young; Lisa A Femia; Piotr Bogorodzki; Jadwiga Rogowska; Deborah A Yurgelun-Todd
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  NeuroImage     Volume:  19     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-01     Completed Date:  2003-10-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1381-94     Citation Subset:  IM    
Affiliation:
Cognitive Neuroimaging Laboratory, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA. william.killgore@na.amedd.army.mil
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MeSH Terms
Descriptor/Qualifier:
Adult
Amygdala / physiology
Appetite / physiology*
Brain Mapping
Cerebellum / physiology
Cerebral Cortex / physiology*
Corpus Callosum / physiology
Dominance, Cerebral / physiology
Energy Intake / physiology*
Female
Food*
Humans
Hypothalamus / physiology
Image Processing, Computer-Assisted*
Imaging, Three-Dimensional*
Limbic System / physiology*
Magnetic Resonance Imaging*
Motivation
Nerve Net / physiology
Pattern Recognition, Visual / physiology*
Prefrontal Cortex / physiology
Reference Values
Somatosensory Cortex / physiology
Thalamus / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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