Document Detail


Cortical language localization in left, dominant hemisphere. An electrical stimulation mapping investigation in 117 patients. 1989.
MedLine Citation:
PMID:  18240946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The localization of cortical sites essential for language was assessed by stimulation mapping in the left, dominant hemispheres of 117 patients. Sites were related to language when stimulation at a current below the threshold for afterdischarge evoked repeated statistically significant errors in object naming. The language center was highly localized in many patients to form several mosaics of 1 to 2 sq cm, usually one in the frontal and one or more in the temporoparietal lobe. The area of individual mosaics, and the total area related to language was usually much smaller than the traditional Broca-Wernicke areas. There was substantial individual variability in the exact location of language function, some of which correlated with the patient's sex and verbal intelligence. These features were present for patients as young as 4 years and as old as 80 years, and for those with lesions acquired in early life or adulthood. These findings indicate a need for revision of the classical model of language localization. The combination of discrete localization in individual patients but substantial individual variability between patients also has major clinical implications for cortical resections of the dominant hemisphere, for it means that language cannot be reliably localized on anatomic criteria alone. A maximal resection with minimal risk of postoperative aphasia requires individual localization of language with a technique like stimulation mapping.
Authors:
George Ojemann; Jeff Ojemann; E Lettich; M Berger
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Publication Detail:
Type:  Biography; Classical Article; Historical Article; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  108     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-21     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA.
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MeSH Terms
Descriptor/Qualifier:
Brain Mapping / methods*
Cerebrum / physiology*
Electric Stimulation
History, 20th Century
Humans
Language*
Neurophysiology / history
Grant Support
ID/Acronym/Agency:
20842//PHS HHS; 21724//PHS HHS; NS17111/NS/NINDS NIH HHS
Personal Name Subject
Personal Name Subject:
George Ojemann; Jeff Ojemann; E Lettich; M Berger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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